Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RNF11Ring finger protein 11. (154 aa)    
Predicted Functional Partners:
ITCH
E3 ubiquitin-protein ligase.
    
 0.957
SMURF2
E3 ubiquitin-protein ligase.
    
 0.931
WWP1
E3 ubiquitin-protein ligase.
    
 0.852
TAX1BP1
Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).
   
 
 0.835
PLA2G4C
Phospholipase A2 group IVC.
      
 0.825
TNFAIP3
TNFAIP3 isoform 1.
   
 
 0.821
UBE2D4
UBE2D4 isoform 3; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.821
NEDD4
E3 ubiquitin-protein ligase.
    
 0.819
NFATC2IP
Nuclear factor of activated T cells 2 interacting protein.
   
 0.811
UBE2N
Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...]
   
 0.806
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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