Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FOXE3LOW QUALITY PROTEIN: forkhead box protein E3. (130 aa)    
Predicted Functional Partners:
PITX3
Homeobox protein.
   
 
 0.736
GPR161
G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.
      
 0.727
HHEX
HHEX isoform 1.
      
 0.505
ITPK1
ITPK1 isoform 3.
    
 
 0.502
NKX2-1
NKX2-1 isoform 1.
   
 0.499
SIVA1
Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
      
 0.477
MSX1
MSX1 isoform 1.
   
 
 0.476
PAX8
Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity).
   
  
 0.466
FBRS
FBRS isoform 1.
  
 
  0.432
PAX6
PAX6 isoform 13.
    
 0.408
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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