Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MKNK1MKNK1 isoform 10; Belongs to the protein kinase superfamily. (418 aa)    
Predicted Functional Partners:
EIF4E
EIF4E isoform 1; Belongs to the eukaryotic initiation factor 4E family.
    
 0.983
MAPK3
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
    
0.967
EIF4E1B
EIF4E1B isoform 2; Belongs to the eukaryotic initiation factor 4E family.
    
 0.965
ATF4
ATF4 isoform 1.
     
 0.902
EIF4E2
Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family.
     
 0.902
MKNK2
MKNK2 isoform 4; Belongs to the protein kinase superfamily.
  
  
 
0.901
MAPK14
Mitogen-activated protein kinase.
    
 
 0.847
ENSPPYP00000013398
annotation not available
    
 
 0.769
MAPK1
Mitogen-activated protein kinase 1 isoform X1.
    
 
 0.769
ENSPPYP00000021743
annotation not available
   
 
 0.737
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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