Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LRRC41Leucine-rich repeat-containing protein 41; Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (738 aa)    
Predicted Functional Partners:
NEURL4
Neuralized E3 ubiquitin protein ligase 4.
     
 0.913
ST6GALNAC6
ST6GALNAC6 isoform 14; Belongs to the glycosyltransferase 29 family.
      
 0.870
FAM124A
Protein FAM124A; Belongs to the FAM124 family.
      
 0.856
AGXT
Serine--pyruvate aminotransferase.
      
 0.790
GZMM
GZMM isoform 2; Belongs to the peptidase S1 family.
      
 0.756
TBC1D2B
TBC1D2B isoform 2.
      
 0.706
CR201_G0003257
COMMD1 isoform 4.
     
  0.653
ASB13
ASB13 isoform 4.
     
 0.644
CUL5
Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]
    
 0.640
KLHL42
Kelch like family member 42.
     
 0.602
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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