IPP protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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[Homology]

Score

IPP

IPP isoform 1. (533 aa)

Predicted Functional Partners:

CUL3

0.831

KLHL28

0.792

KLHL26

0.766

MINPP1

0.625

RBX1

0.595

CUL1

0.520

NANP

0.511

UBXN7

0.503

CYB561A3

0.493

KLHL9

0.487

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL1	CUL3	ENSPPYP00000020352	ENSPPYP00000014786	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	CUL3 isoform 1; Belongs to the cullin family.	0.878
CUL1	IPP	ENSPPYP00000020352	ENSPPYP00000001629	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	IPP isoform 1.	0.520
CUL1	KLHL28	ENSPPYP00000020352	ENSPPYP00000006563	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	Kelch like family member 28.	0.457
CUL1	RBX1	ENSPPYP00000020352	ENSPPYP00000013235	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	RBX1 isoform 1.	0.999
CUL1	UBXN7	ENSPPYP00000020352	ENSPPYP00000016149	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	UBX domain-containing protein 7; Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity).	0.954
CUL3	CUL1	ENSPPYP00000014786	ENSPPYP00000020352	CUL3 isoform 1; Belongs to the cullin family.	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	0.878
CUL3	IPP	ENSPPYP00000014786	ENSPPYP00000001629	CUL3 isoform 1; Belongs to the cullin family.	IPP isoform 1.	0.831
CUL3	KLHL26	ENSPPYP00000014786	ENSPPYP00000010921	CUL3 isoform 1; Belongs to the cullin family.	KLHL26 isoform 1.	0.877
CUL3	KLHL28	ENSPPYP00000014786	ENSPPYP00000006563	CUL3 isoform 1; Belongs to the cullin family.	Kelch like family member 28.	0.800
CUL3	KLHL9	ENSPPYP00000014786	ENSPPYP00000021487	CUL3 isoform 1; Belongs to the cullin family.	Kelch like family member 9.	0.981
CUL3	RBX1	ENSPPYP00000014786	ENSPPYP00000013235	CUL3 isoform 1; Belongs to the cullin family.	RBX1 isoform 1.	0.998
CUL3	UBXN7	ENSPPYP00000014786	ENSPPYP00000016149	CUL3 isoform 1; Belongs to the cullin family.	UBX domain-containing protein 7; Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity).	0.953
CYB561A3	IPP	ENSPPYP00000003681	ENSPPYP00000001629	Cytochrome b561 family member A3.	IPP isoform 1.	0.493
IPP	CUL1	ENSPPYP00000001629	ENSPPYP00000020352	IPP isoform 1.	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	0.520
IPP	CUL3	ENSPPYP00000001629	ENSPPYP00000014786	IPP isoform 1.	CUL3 isoform 1; Belongs to the cullin family.	0.831
IPP	CYB561A3	ENSPPYP00000001629	ENSPPYP00000003681	IPP isoform 1.	Cytochrome b561 family member A3.	0.493
IPP	KLHL26	ENSPPYP00000001629	ENSPPYP00000010921	IPP isoform 1.	KLHL26 isoform 1.	0.766
IPP	KLHL28	ENSPPYP00000001629	ENSPPYP00000006563	IPP isoform 1.	Kelch like family member 28.	0.792
IPP	KLHL9	ENSPPYP00000001629	ENSPPYP00000021487	IPP isoform 1.	Kelch like family member 9.	0.487
IPP	MINPP1	ENSPPYP00000001629	ENSPPYP00000002842	IPP isoform 1.	Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3- bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity); Belongs [...]	0.625