Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HPDL4-hydroxyphenylpyruvate dioxygenase. (371 aa)    
Predicted Functional Partners:
HGD
Homogentisate 1,2-dioxygenase; Belongs to the homogentisate dioxygenase family.
  
 0.957
TAT
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
   
 
 0.810
PCCB
PCCB isoform 8.
  
 
 0.751
MCCC2
MCCC2 isoform 1.
  
 
 0.751
FAH
Fumarylacetoacetase.
 
  
 0.723
COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
     
 0.621
GSTZ1
Glutathione S-transferase zeta 1; Belongs to the GST superfamily.
  
  
 0.619
PCCA
PCCA isoform 3.
  
 
 0.608
NELFCD
Negative elongation factor D; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity).
  
 
 0.608
MCCC1
Methylcrotonoyl-CoA carboxylase 1.
  
 
 0.608
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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