Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
BEST4Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (473 aa)    
Predicted Functional Partners:
OTOP2
OTOP2 isoform 2.
   
  
 0.580
CR201_G0008574
DEPDC1 isoform 1.
      
 0.531
RPE65
Retinoid isomerohydrolase RPE65.
      
 0.531
ANO1
Anoctamin.
      
 0.527
CA7
Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family.
   
  
 0.526
LRRC8A
Leucine rich repeat containing 8 VRAC subunit A.
      
 0.517
TTR
Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family.
      
 0.511
TTYH1
Protein tweety homolog; Probable chloride channel; Belongs to the tweety family.
      
 0.488
GLUL
Glutamine synthetase.
    
 
 0.443
MERTK
MERTK isoform 2.
      
 0.429
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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