Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RNF220RNF220 isoform 1. (540 aa)    
Predicted Functional Partners:
ZC4H2
ZC4H2 isoform 7.
    
 
 0.930
CCDC24
CCDC24 isoform 2.
      
 0.726
SIN3B
SIN3B isoform 1.
    
 
 0.649
SLC24A2
SLC24A2 isoform 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
      
 0.631
VRK1
VRK1 isoform 2; Belongs to the protein kinase superfamily.
    
 0.574
ERI3
ERI3 isoform 4.
      
 0.570
USP7
USP7 isoform 8; Belongs to the peptidase C19 family.
    
 
 0.570
FBXO3
F-box protein 3.
      
 0.568
SIN3A
SIN3 transcription regulator family member A.
    
 
 0.553
CUL7
Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin- protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...]
    
 
 0.553
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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