node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGXT2 | DAO | ENSPPYP00000017192 | ENSPPYP00000005617 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | DAO isoform 1. | 0.934 |
AGXT2 | GRHPR | ENSPPYP00000017192 | ENSPPYP00000021363 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | GRHPR isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.856 |
AGXT2 | HYI | ENSPPYP00000017192 | ENSPPYP00000001674 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | 0.813 |
DAO | AGXT2 | ENSPPYP00000005617 | ENSPPYP00000017192 | DAO isoform 1. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.934 |
DAO | GRHPR | ENSPPYP00000005617 | ENSPPYP00000021363 | DAO isoform 1. | GRHPR isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.864 |
DAO | HYI | ENSPPYP00000005617 | ENSPPYP00000001674 | DAO isoform 1. | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | 0.800 |
DOHH | HYI | ENSPPYP00000010514 | ENSPPYP00000001674 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family. | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | 0.450 |
GLYCTK | GRHPR | ENSPPYP00000015455 | ENSPPYP00000021363 | GLYCTK isoform 6. | GRHPR isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.841 |
GLYCTK | HYI | ENSPPYP00000015455 | ENSPPYP00000001674 | GLYCTK isoform 6. | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | 0.514 |
GRHPR | AGXT2 | ENSPPYP00000021363 | ENSPPYP00000017192 | GRHPR isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.856 |
GRHPR | DAO | ENSPPYP00000021363 | ENSPPYP00000005617 | GRHPR isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | DAO isoform 1. | 0.864 |
GRHPR | GLYCTK | ENSPPYP00000021363 | ENSPPYP00000015455 | GRHPR isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | GLYCTK isoform 6. | 0.841 |
GRHPR | HYI | ENSPPYP00000021363 | ENSPPYP00000001674 | GRHPR isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | 0.930 |
HYI | AGXT2 | ENSPPYP00000001674 | ENSPPYP00000017192 | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.813 |
HYI | DAO | ENSPPYP00000001674 | ENSPPYP00000005617 | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | DAO isoform 1. | 0.800 |
HYI | DOHH | ENSPPYP00000001674 | ENSPPYP00000010514 | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family. | 0.450 |
HYI | GLYCTK | ENSPPYP00000001674 | ENSPPYP00000015455 | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | GLYCTK isoform 6. | 0.514 |
HYI | GRHPR | ENSPPYP00000001674 | ENSPPYP00000021363 | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. | GRHPR isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.930 |