SZT2 protein (Pongo abelii) - STRING interaction network

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SZT2

SZT2 isoform 1. (2688 aa)

Predicted Functional Partners:

ITFG2

0.924

C12orf66

0.849

KPTN

0.790

RHBDL2

0.634

DGKE

0.570

CUL9

0.547

CR201_G0012162

0.533

RNF149

0.533

MTRR

0.528

OTUD3

0.520

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C12orf66	ITFG2	ENSPPYP00000005382	ENSPPYP00000004733	C12orf66 isoform 1.	KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	0.998
C12orf66	KPTN	ENSPPYP00000005382	ENSPPYP00000011380	C12orf66 isoform 1.	KPTN isoform 1.	0.996
C12orf66	OTUD3	ENSPPYP00000005382	ENSPPYP00000002065	C12orf66 isoform 1.	OTUD3 isoform 1.	0.433
C12orf66	SZT2	ENSPPYP00000005382	ENSPPYP00000001675	C12orf66 isoform 1.	SZT2 isoform 1.	0.849
CR201_G0012162	DGKE	ENSPPYP00000009270	ENSPPYP00000009269	C17orf67 isoform 2.	Diacylglycerol kinase.	0.528
CR201_G0012162	RHBDL2	ENSPPYP00000009270	ENSPPYP00000001748	C17orf67 isoform 2.	Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	0.451
CR201_G0012162	SZT2	ENSPPYP00000009270	ENSPPYP00000001675	C17orf67 isoform 2.	SZT2 isoform 1.	0.533
CUL9	SZT2	ENSPPYP00000018607	ENSPPYP00000001675	CUL9 isoform 1; Belongs to the cullin family.	SZT2 isoform 1.	0.547
DGKE	CR201_G0012162	ENSPPYP00000009269	ENSPPYP00000009270	Diacylglycerol kinase.	C17orf67 isoform 2.	0.528
DGKE	SZT2	ENSPPYP00000009269	ENSPPYP00000001675	Diacylglycerol kinase.	SZT2 isoform 1.	0.570
ITFG2	C12orf66	ENSPPYP00000004733	ENSPPYP00000005382	KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	C12orf66 isoform 1.	0.998
ITFG2	KPTN	ENSPPYP00000004733	ENSPPYP00000011380	KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	KPTN isoform 1.	0.997
ITFG2	OTUD3	ENSPPYP00000004733	ENSPPYP00000002065	KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	OTUD3 isoform 1.	0.718
ITFG2	SZT2	ENSPPYP00000004733	ENSPPYP00000001675	KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	SZT2 isoform 1.	0.924
KPTN	C12orf66	ENSPPYP00000011380	ENSPPYP00000005382	KPTN isoform 1.	C12orf66 isoform 1.	0.996
KPTN	ITFG2	ENSPPYP00000011380	ENSPPYP00000004733	KPTN isoform 1.	KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	0.997
KPTN	OTUD3	ENSPPYP00000011380	ENSPPYP00000002065	KPTN isoform 1.	OTUD3 isoform 1.	0.411
KPTN	SZT2	ENSPPYP00000011380	ENSPPYP00000001675	KPTN isoform 1.	SZT2 isoform 1.	0.790
MTRR	SZT2	ENSPPYP00000017133	ENSPPYP00000001675	MTRR isoform 12.	SZT2 isoform 1.	0.528
OTUD3	C12orf66	ENSPPYP00000002065	ENSPPYP00000005382	OTUD3 isoform 1.	C12orf66 isoform 1.	0.433