Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EDN2EDN2 isoform 2. (178 aa)    
Predicted Functional Partners:
EDNRA
EDNRA isoform 1; Belongs to the G-protein coupled receptor 1 family.
     
 0.989
EDNRB
Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.
     
 0.978
EDN1
EDN1 isoform 1.
   
 
0.946
EDN3
EDN3 isoform 1.
     
0.935
OXTR
Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
     
 0.770
KITLG
Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.
      
 0.727
GHSR
Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.
     
  0.714
AGTR2
Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.
     
 0.706
ADRB2
Adrenoceptor beta 2.
     
 0.698
HTR1D
5-hydroxytryptamine receptor 1D.
     
 0.697
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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