Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FOXO6FOXO6 isoform 2. (138 aa)    
Predicted Functional Partners:
AKT1
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.978
AKT3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.976
AKT2
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.976
USP7
USP7 isoform 8; Belongs to the peptidase C19 family.
   
 0.964
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
    
 0.959
SGK1
Non-specific serine/threonine protein kinase.
    
 0.959
SGK2
Serum/glucocorticoid-regulated kinase 2.
    
 0.948
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
    
 0.946
MAPK8
Mitogen-activated protein kinase.
    
 0.945
SIRT1
SIRT1 isoform 1.
    
 0.945
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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