MFSD2A protein (Pongo abelii) - STRING interaction network

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MFSD2A

Major facilitator superfamily domain containing 2A. (530 aa)

Predicted Functional Partners:

CLDN5

0.659

SASS6

0.630

ZNF335

0.623

OCLN

0.621

GIPR

0.614

SLC2A1

0.554

CAV1

0.553

TYMS

0.542

TK1

0.533

PLVAP

0.526

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	CLDN5	ENSPPYP00000020105	ENSPPYP00000012919	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.457
CAV1	MFSD2A	ENSPPYP00000020105	ENSPPYP00000001730	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	Major facilitator superfamily domain containing 2A.	0.553
CAV1	PLVAP	ENSPPYP00000020105	ENSPPYP00000023790	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	PLVAP isoform 1.	0.508
CLDN5	CAV1	ENSPPYP00000012919	ENSPPYP00000020105	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	0.457
CLDN5	MFSD2A	ENSPPYP00000012919	ENSPPYP00000001730	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Major facilitator superfamily domain containing 2A.	0.659
CLDN5	OCLN	ENSPPYP00000012919	ENSPPYP00000017356	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.	0.935
CLDN5	PLVAP	ENSPPYP00000012919	ENSPPYP00000023790	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	PLVAP isoform 1.	0.548
GIPR	MFSD2A	ENSPPYP00000011327	ENSPPYP00000001730	GIPR isoform 4; Belongs to the G-protein coupled receptor 2 family.	Major facilitator superfamily domain containing 2A.	0.614
MFSD2A	CAV1	ENSPPYP00000001730	ENSPPYP00000020105	Major facilitator superfamily domain containing 2A.	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	0.553
MFSD2A	CLDN5	ENSPPYP00000001730	ENSPPYP00000012919	Major facilitator superfamily domain containing 2A.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.659
MFSD2A	GIPR	ENSPPYP00000001730	ENSPPYP00000011327	Major facilitator superfamily domain containing 2A.	GIPR isoform 4; Belongs to the G-protein coupled receptor 2 family.	0.614
MFSD2A	OCLN	ENSPPYP00000001730	ENSPPYP00000017356	Major facilitator superfamily domain containing 2A.	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.	0.621
MFSD2A	PLVAP	ENSPPYP00000001730	ENSPPYP00000023790	Major facilitator superfamily domain containing 2A.	PLVAP isoform 1.	0.526
MFSD2A	SASS6	ENSPPYP00000001730	ENSPPYP00000001299	Major facilitator superfamily domain containing 2A.	SAS-6 centriolar assembly protein.	0.630
MFSD2A	SLC2A1	ENSPPYP00000001730	ENSPPYP00000001688	Major facilitator superfamily domain containing 2A.	SLC2A1 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.554
MFSD2A	TK1	ENSPPYP00000001730	ENSPPYP00000009752	Major facilitator superfamily domain containing 2A.	Thymidine kinase.	0.533
MFSD2A	TYMS	ENSPPYP00000001730	ENSPPYP00000010155	Major facilitator superfamily domain containing 2A.	Thymidylate synthetase.	0.542
MFSD2A	ZNF335	ENSPPYP00000001730	ENSPPYP00000012385	Major facilitator superfamily domain containing 2A.	ZNF335 isoform 1.	0.623
OCLN	CLDN5	ENSPPYP00000017356	ENSPPYP00000012919	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.935
OCLN	MFSD2A	ENSPPYP00000017356	ENSPPYP00000001730	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.	Major facilitator superfamily domain containing 2A.	0.621