HEYL protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

HEYL

Hes related family bHLH transcription factor with YRPW motif like. (328 aa)

Predicted Functional Partners:

HEY2

0.928

HEY1

0.924

PGGT1B

0.824

RBPJ

0.686

NOTCH3

0.678

NOTCH1

0.668

HES1

0.577

NOTCH4

0.558

DLL4

0.543

ENSPPYP00000018739

0.537

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL4	ENSPPYP00000018739	ENSPPYP00000024574	ENSPPYP00000018739	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	annotation not available	0.893
DLL4	HES1	ENSPPYP00000024574	ENSPPYP00000016129	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	HES1 isoform 1.	0.519
DLL4	HEY1	ENSPPYP00000024574	ENSPPYP00000020968	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes related family bHLH transcription factor with YRPW motif 1.	0.632
DLL4	HEY2	ENSPPYP00000024574	ENSPPYP00000019021	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes related family bHLH transcription factor with YRPW motif 2.	0.548
DLL4	HEYL	ENSPPYP00000024574	ENSPPYP00000001740	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes related family bHLH transcription factor with YRPW motif like.	0.543
DLL4	NOTCH1	ENSPPYP00000024574	ENSPPYP00000022176	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH1 isoform 1.	0.930
DLL4	NOTCH3	ENSPPYP00000024574	ENSPPYP00000010835	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH3 isoform 1.	0.993
DLL4	NOTCH4	ENSPPYP00000024574	ENSPPYP00000018437	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH4 isoform 1.	0.819
DLL4	RBPJ	ENSPPYP00000024574	ENSPPYP00000016373	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...]	0.627
ENSPPYP00000018739	DLL4	ENSPPYP00000018739	ENSPPYP00000024574	annotation not available	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.893
ENSPPYP00000018739	HES1	ENSPPYP00000018739	ENSPPYP00000016129	annotation not available	HES1 isoform 1.	0.703
ENSPPYP00000018739	HEY1	ENSPPYP00000018739	ENSPPYP00000020968	annotation not available	Hes related family bHLH transcription factor with YRPW motif 1.	0.537
ENSPPYP00000018739	HEY2	ENSPPYP00000018739	ENSPPYP00000019021	annotation not available	Hes related family bHLH transcription factor with YRPW motif 2.	0.537
ENSPPYP00000018739	HEYL	ENSPPYP00000018739	ENSPPYP00000001740	annotation not available	Hes related family bHLH transcription factor with YRPW motif like.	0.537
ENSPPYP00000018739	NOTCH3	ENSPPYP00000018739	ENSPPYP00000010835	annotation not available	NOTCH3 isoform 1.	0.843
ENSPPYP00000018739	NOTCH4	ENSPPYP00000018739	ENSPPYP00000018437	annotation not available	NOTCH4 isoform 1.	0.796
ENSPPYP00000018739	RBPJ	ENSPPYP00000018739	ENSPPYP00000016373	annotation not available	Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...]	0.910
HES1	DLL4	ENSPPYP00000016129	ENSPPYP00000024574	HES1 isoform 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.519
HES1	ENSPPYP00000018739	ENSPPYP00000016129	ENSPPYP00000018739	HES1 isoform 1.	annotation not available	0.703
HES1	HEY1	ENSPPYP00000016129	ENSPPYP00000020968	HES1 isoform 1.	Hes related family bHLH transcription factor with YRPW motif 1.	0.883