MACF1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

MACF1

Microtubule actin crosslinking factor 1. (5430 aa)

Predicted Functional Partners:

PLEC

0.882

ENSPPYP00000023839

0.882

DST

0.874

JUP

0.797

MAPRE1

0.795

COL17A1

0.730

TTI1

0.712

ITGB4

0.700

PKP2

0.672

SPTAN1

0.629

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL17A1	DST	ENSPPYP00000003060	ENSPPYP00000018724	COL17A1 isoform 2.	DST isoform 3.	0.917
COL17A1	ENSPPYP00000023839	ENSPPYP00000003060	ENSPPYP00000023839	COL17A1 isoform 2.	annotation not available	0.675
COL17A1	ITGB4	ENSPPYP00000003060	ENSPPYP00000009696	COL17A1 isoform 2.	Integrin beta.	0.905
COL17A1	MACF1	ENSPPYP00000003060	ENSPPYP00000001743	COL17A1 isoform 2.	Microtubule actin crosslinking factor 1.	0.730
COL17A1	PLEC	ENSPPYP00000003060	ENSPPYP00000021319	COL17A1 isoform 2.	PLEC isoform 2.	0.675
DST	COL17A1	ENSPPYP00000018724	ENSPPYP00000003060	DST isoform 3.	COL17A1 isoform 2.	0.917
DST	ENSPPYP00000023839	ENSPPYP00000018724	ENSPPYP00000023839	DST isoform 3.	annotation not available	0.796
DST	ITGB4	ENSPPYP00000018724	ENSPPYP00000009696	DST isoform 3.	Integrin beta.	0.784
DST	JUP	ENSPPYP00000018724	ENSPPYP00000009456	DST isoform 3.	JUP isoform 1.	0.797
DST	MACF1	ENSPPYP00000018724	ENSPPYP00000001743	DST isoform 3.	Microtubule actin crosslinking factor 1.	0.874
DST	MAPRE1	ENSPPYP00000018724	ENSPPYP00000012189	DST isoform 3.	Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, a [...]	0.922
DST	PKP2	ENSPPYP00000018724	ENSPPYP00000005030	DST isoform 3.	PKP2 isoform 2.	0.672
DST	PLEC	ENSPPYP00000018724	ENSPPYP00000021319	DST isoform 3.	PLEC isoform 2.	0.796
DST	SPTAN1	ENSPPYP00000018724	ENSPPYP00000022030	DST isoform 3.	SPTAN1 isoform 10.	0.618
DST	TTI1	ENSPPYP00000018724	ENSPPYP00000012276	DST isoform 3.	TELO2 interacting protein 1.	0.470
ENSPPYP00000023839	COL17A1	ENSPPYP00000023839	ENSPPYP00000003060	annotation not available	COL17A1 isoform 2.	0.675
ENSPPYP00000023839	DST	ENSPPYP00000023839	ENSPPYP00000018724	annotation not available	DST isoform 3.	0.796
ENSPPYP00000023839	ITGB4	ENSPPYP00000023839	ENSPPYP00000009696	annotation not available	Integrin beta.	0.923
ENSPPYP00000023839	JUP	ENSPPYP00000023839	ENSPPYP00000009456	annotation not available	JUP isoform 1.	0.889
ENSPPYP00000023839	MACF1	ENSPPYP00000023839	ENSPPYP00000001743	annotation not available	Microtubule actin crosslinking factor 1.	0.882