Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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RHBDL2Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (303 aa)    
Predicted Functional Partners:
SZT2
SZT2 isoform 1.
      
 0.634
ENSPPYP00000009939
annotation not available
    
 
 0.618
ANKRD22
ANKRD22 isoform 1.
      
 0.585
EPHB4
EPHB4 isoform 2.
   
  
 0.575
PARL
Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity).
      
 0.535
CSK
Tyrosine-protein kinase.
    
 
 0.512
EFNB2
EFNB2 isoform 1; Belongs to the ephrin family.
    
 
 0.502
APH1A
Aph-1 homolog A, gamma-secretase subunit.
   
  
 0.489
NCSTN
NCSTN isoform 1.
      
 0.481
RAB34
RAB34 isoform 8.
      
 0.468
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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