CSMD2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BPIFB4	CSMD2	ENSPPYP00000012601	ENSPPYP00000001812	BPIFB4 isoform 2.	CSMD2 isoform 4.	0.504
BPIFB4	FAU	ENSPPYP00000012601	ENSPPYP00000003561	BPIFB4 isoform 2.	Ubiquitin-like protein FUBI.	0.485
BPIFB4	KLRD1	ENSPPYP00000012601	ENSPPYP00000004870	BPIFB4 isoform 2.	KLRD1 isoform 1.	0.619
BPIFB4	SCN9A	ENSPPYP00000012601	ENSPPYP00000014397	BPIFB4 isoform 2.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.418
CSMD2	BPIFB4	ENSPPYP00000001812	ENSPPYP00000012601	CSMD2 isoform 4.	BPIFB4 isoform 2.	0.504
CSMD2	DISC1	ENSPPYP00000001812	ENSPPYP00000000112	CSMD2 isoform 4.	DISC1 scaffold protein.	0.481
CSMD2	ERAP2	ENSPPYP00000001812	ENSPPYP00000017500	CSMD2 isoform 4.	Endoplasmic reticulum aminopeptidase 2; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys (By similarity).	0.516
CSMD2	FAU	ENSPPYP00000001812	ENSPPYP00000003561	CSMD2 isoform 4.	Ubiquitin-like protein FUBI.	0.738
CSMD2	KLRD1	ENSPPYP00000001812	ENSPPYP00000004870	CSMD2 isoform 4.	KLRD1 isoform 1.	0.609
CSMD2	LRRC41	ENSPPYP00000001812	ENSPPYP00000001619	CSMD2 isoform 4.	Leucine-rich repeat-containing protein 41; Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	0.500
CSMD2	PDE1A	ENSPPYP00000001812	ENSPPYP00000014514	CSMD2 isoform 4.	Phosphodiesterase.	0.653
CSMD2	SCN7A	ENSPPYP00000001812	ENSPPYP00000014398	CSMD2 isoform 4.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.492
CSMD2	SCN9A	ENSPPYP00000001812	ENSPPYP00000014397	CSMD2 isoform 4.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.666
CSMD2	TNR	ENSPPYP00000001812	ENSPPYP00000000555	CSMD2 isoform 4.	TNR isoform 1.	0.446
DISC1	CSMD2	ENSPPYP00000000112	ENSPPYP00000001812	DISC1 scaffold protein.	CSMD2 isoform 4.	0.481
DISC1	TNR	ENSPPYP00000000112	ENSPPYP00000000555	DISC1 scaffold protein.	TNR isoform 1.	0.446
ERAP2	CSMD2	ENSPPYP00000017500	ENSPPYP00000001812	Endoplasmic reticulum aminopeptidase 2; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys (By similarity).	CSMD2 isoform 4.	0.516
ERAP2	FAU	ENSPPYP00000017500	ENSPPYP00000003561	Endoplasmic reticulum aminopeptidase 2; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys (By similarity).	Ubiquitin-like protein FUBI.	0.499
FAU	BPIFB4	ENSPPYP00000003561	ENSPPYP00000012601	Ubiquitin-like protein FUBI.	BPIFB4 isoform 2.	0.485
FAU	CSMD2	ENSPPYP00000003561	ENSPPYP00000001812	Ubiquitin-like protein FUBI.	CSMD2 isoform 4.	0.738