| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BMI1 | CBX4 | ENSPPYP00000002492 | ENSPPYP00000009774 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] | CBX4 isoform 2. | 0.991 |
| BMI1 | CBX6 | ENSPPYP00000002492 | ENSPPYP00000013197 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] | CBX6 isoform 1. | 0.894 |
| BMI1 | CBX8 | ENSPPYP00000002492 | ENSPPYP00000024136 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] | CBX8 isoform 1. | 0.986 |
| BMI1 | CR201_G0021544 | ENSPPYP00000002492 | ENSPPYP00000009773 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] | CBX2 isoform 1. | 0.923 |
| BMI1 | PCGF2 | ENSPPYP00000002492 | ENSPPYP00000009558 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] | PCGF2 isoform 1. | 0.991 |
| BMI1 | PHC2 | ENSPPYP00000002492 | ENSPPYP00000001815 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] | PHC2 isoform 4. | 0.966 |
| BMI1 | PHC3 | ENSPPYP00000002492 | ENSPPYP00000015970 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] | Polyhomeotic homolog 3. | 0.852 |
| BMI1 | RING1 | ENSPPYP00000002492 | ENSPPYP00000019327 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] | Ring finger protein 1. | 0.992 |
| BMI1 | RNF2 | ENSPPYP00000002492 | ENSPPYP00000000473 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] | 0.998 |
| BMI1 | SCML2 | ENSPPYP00000002492 | ENSPPYP00000022558 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] | SCML2 isoform 1. | 0.900 |
| CBX4 | BMI1 | ENSPPYP00000009774 | ENSPPYP00000002492 | CBX4 isoform 2. | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] | 0.991 |
| CBX4 | CBX6 | ENSPPYP00000009774 | ENSPPYP00000013197 | CBX4 isoform 2. | CBX6 isoform 1. | 0.697 |
| CBX4 | CBX8 | ENSPPYP00000009774 | ENSPPYP00000024136 | CBX4 isoform 2. | CBX8 isoform 1. | 0.996 |
| CBX4 | CR201_G0021544 | ENSPPYP00000009774 | ENSPPYP00000009773 | CBX4 isoform 2. | CBX2 isoform 1. | 0.979 |
| CBX4 | PCGF2 | ENSPPYP00000009774 | ENSPPYP00000009558 | CBX4 isoform 2. | PCGF2 isoform 1. | 0.995 |
| CBX4 | PHC2 | ENSPPYP00000009774 | ENSPPYP00000001815 | CBX4 isoform 2. | PHC2 isoform 4. | 0.985 |
| CBX4 | PHC3 | ENSPPYP00000009774 | ENSPPYP00000015970 | CBX4 isoform 2. | Polyhomeotic homolog 3. | 0.887 |
| CBX4 | RING1 | ENSPPYP00000009774 | ENSPPYP00000019327 | CBX4 isoform 2. | Ring finger protein 1. | 0.996 |
| CBX4 | RNF2 | ENSPPYP00000009774 | ENSPPYP00000000473 | CBX4 isoform 2. | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] | 0.996 |
| CBX4 | SCML2 | ENSPPYP00000009774 | ENSPPYP00000022558 | CBX4 isoform 2. | SCML2 isoform 1. | 0.887 |
