TSSK3 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TSSK3

Testis specific serine kinase 3. (268 aa)

Predicted Functional Partners:

TSKS

0.698

GAPVD1

0.666

SNX24

0.661

DDIT4L

0.635

RSPH1

0.631

RPTOR

0.590

PRKAB2

0.576

PRKAB1

0.576

TBX4

0.567

PRKAG1

0.557

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDIT4L	TSSK3	ENSPPYP00000016703	ENSPPYP00000001836	DNA damage-inducible transcript 4-like protein; Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Belongs to the DDIT4 family.	Testis specific serine kinase 3.	0.635
GAPVD1	SNX24	ENSPPYP00000021974	ENSPPYP00000017580	GTPase activating protein and VPS9 domains 1.	Sorting nexin 24.	0.804
GAPVD1	TSSK3	ENSPPYP00000021974	ENSPPYP00000001836	GTPase activating protein and VPS9 domains 1.	Testis specific serine kinase 3.	0.666
PRKAB1	PRKAB2	ENSPPYP00000005719	ENSPPYP00000001096	5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...]	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.997
PRKAB1	PRKAG1	ENSPPYP00000005719	ENSPPYP00000005111	5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...]	Protein kinase AMP-activated non-catalytic subunit gamma 1.	0.999
PRKAB1	RPTOR	ENSPPYP00000005719	ENSPPYP00000024617	5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...]	RPTOR isoform 4.	0.977
PRKAB1	TSSK3	ENSPPYP00000005719	ENSPPYP00000001836	5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...]	Testis specific serine kinase 3.	0.576
PRKAB2	PRKAB1	ENSPPYP00000001096	ENSPPYP00000005719	Protein kinase AMP-activated non-catalytic subunit beta 2.	5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...]	0.997
PRKAB2	PRKAG1	ENSPPYP00000001096	ENSPPYP00000005111	Protein kinase AMP-activated non-catalytic subunit beta 2.	Protein kinase AMP-activated non-catalytic subunit gamma 1.	0.999
PRKAB2	RPTOR	ENSPPYP00000001096	ENSPPYP00000024617	Protein kinase AMP-activated non-catalytic subunit beta 2.	RPTOR isoform 4.	0.982
PRKAB2	TSSK3	ENSPPYP00000001096	ENSPPYP00000001836	Protein kinase AMP-activated non-catalytic subunit beta 2.	Testis specific serine kinase 3.	0.576
PRKAG1	PRKAB1	ENSPPYP00000005111	ENSPPYP00000005719	Protein kinase AMP-activated non-catalytic subunit gamma 1.	5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...]	0.999
PRKAG1	PRKAB2	ENSPPYP00000005111	ENSPPYP00000001096	Protein kinase AMP-activated non-catalytic subunit gamma 1.	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.999
PRKAG1	RPTOR	ENSPPYP00000005111	ENSPPYP00000024617	Protein kinase AMP-activated non-catalytic subunit gamma 1.	RPTOR isoform 4.	0.973
PRKAG1	TSSK3	ENSPPYP00000005111	ENSPPYP00000001836	Protein kinase AMP-activated non-catalytic subunit gamma 1.	Testis specific serine kinase 3.	0.557
RPTOR	PRKAB1	ENSPPYP00000024617	ENSPPYP00000005719	RPTOR isoform 4.	5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...]	0.977
RPTOR	PRKAB2	ENSPPYP00000024617	ENSPPYP00000001096	RPTOR isoform 4.	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.982
RPTOR	PRKAG1	ENSPPYP00000024617	ENSPPYP00000005111	RPTOR isoform 4.	Protein kinase AMP-activated non-catalytic subunit gamma 1.	0.973
RPTOR	TSSK3	ENSPPYP00000024617	ENSPPYP00000001836	RPTOR isoform 4.	Testis specific serine kinase 3.	0.590
RSPH1	TSSK3	ENSPPYP00000012786	ENSPPYP00000001836	Radial spoke head component 1.	Testis specific serine kinase 3.	0.631