KHDRBS1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KHDRBS1

KHDRBS1 isoform 2. (547 aa)

Predicted Functional Partners:

SRC

0.970

PTK6

0.969

FYN

0.962

RASA1

0.953

GRB2

0.921

PLCG1

0.920

ENSPPYP00000011486

0.898

DHX9

0.895

APC

0.890

KHDRBS3

0.872

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APC	KHDRBS1	ENSPPYP00000024042	ENSPPYP00000001850	Adenomatous polyposis coli protein isoform X2.	KHDRBS1 isoform 2.	0.890
APC	KHDRBS3	ENSPPYP00000024042	ENSPPYP00000023686	Adenomatous polyposis coli protein isoform X2.	KHDRBS3 isoform 5.	0.478
DHX9	KHDRBS1	ENSPPYP00000000490	ENSPPYP00000001850	ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA a [...]	KHDRBS1 isoform 2.	0.895
DHX9	KHDRBS3	ENSPPYP00000000490	ENSPPYP00000023686	ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA a [...]	KHDRBS3 isoform 5.	0.405
ENSPPYP00000011486	KHDRBS1	ENSPPYP00000011486	ENSPPYP00000001850	annotation not available	KHDRBS1 isoform 2.	0.898
ENSPPYP00000011486	KHDRBS3	ENSPPYP00000011486	ENSPPYP00000023686	annotation not available	KHDRBS3 isoform 5.	0.563
ENSPPYP00000011486	SRC	ENSPPYP00000011486	ENSPPYP00000012270	annotation not available	Tyrosine-protein kinase.	0.576
FYN	GRB2	ENSPPYP00000018952	ENSPPYP00000009686	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	0.880
FYN	KHDRBS1	ENSPPYP00000018952	ENSPPYP00000001850	Tyrosine-protein kinase.	KHDRBS1 isoform 2.	0.962
FYN	KHDRBS3	ENSPPYP00000018952	ENSPPYP00000023686	Tyrosine-protein kinase.	KHDRBS3 isoform 5.	0.519
FYN	PLCG1	ENSPPYP00000018952	ENSPPYP00000012298	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.704
FYN	RASA1	ENSPPYP00000018952	ENSPPYP00000017460	Tyrosine-protein kinase.	RASA1 isoform 1.	0.405
FYN	SRC	ENSPPYP00000018952	ENSPPYP00000012270	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.999
GRB2	FYN	ENSPPYP00000009686	ENSPPYP00000018952	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	Tyrosine-protein kinase.	0.880
GRB2	KHDRBS1	ENSPPYP00000009686	ENSPPYP00000001850	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	KHDRBS1 isoform 2.	0.921
GRB2	PLCG1	ENSPPYP00000009686	ENSPPYP00000012298	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.987
GRB2	PTK6	ENSPPYP00000009686	ENSPPYP00000012555	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	Tyrosine-protein kinase.	0.592
GRB2	RASA1	ENSPPYP00000009686	ENSPPYP00000017460	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	RASA1 isoform 1.	0.422
GRB2	SRC	ENSPPYP00000009686	ENSPPYP00000012270	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.	Tyrosine-protein kinase.	0.991
KHDRBS1	APC	ENSPPYP00000001850	ENSPPYP00000024042	KHDRBS1 isoform 2.	Adenomatous polyposis coli protein isoform X2.	0.890