PUM1 protein (Pongo abelii) - STRING interaction network

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PUM1

Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...] (1212 aa)

Predicted Functional Partners:

PUM2

0.976

ATXN1

0.912

ATXN1L

0.901

CLINT1

0.861

FUBP3

0.814

COX17

0.748

SUPV3L1

0.719

TOMM22

0.712

MRPL19

0.710

SH3D19

0.701

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN1	ATXN1L	ENSPPYP00000018177	ENSPPYP00000024016	ATXN1 isoform 1.	ATXN1L isoform 2.	0.924
ATXN1	PUM1	ENSPPYP00000018177	ENSPPYP00000001871	ATXN1 isoform 1.	Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...]	0.912
ATXN1	PUM2	ENSPPYP00000018177	ENSPPYP00000014090	ATXN1 isoform 1.	Pumilio RNA binding family member 2.	0.910
ATXN1L	ATXN1	ENSPPYP00000024016	ENSPPYP00000018177	ATXN1L isoform 2.	ATXN1 isoform 1.	0.924
ATXN1L	PUM1	ENSPPYP00000024016	ENSPPYP00000001871	ATXN1L isoform 2.	Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...]	0.901
ATXN1L	PUM2	ENSPPYP00000024016	ENSPPYP00000014090	ATXN1L isoform 2.	Pumilio RNA binding family member 2.	0.901
CLINT1	FUBP3	ENSPPYP00000017899	ENSPPYP00000022072	CLINT1 isoform 1.	Far upstream element binding protein 3.	0.450
CLINT1	PUM1	ENSPPYP00000017899	ENSPPYP00000001871	CLINT1 isoform 1.	Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...]	0.861
CLINT1	PUM2	ENSPPYP00000017899	ENSPPYP00000014090	CLINT1 isoform 1.	Pumilio RNA binding family member 2.	0.751
CLINT1	SH3D19	ENSPPYP00000017899	ENSPPYP00000016895	CLINT1 isoform 1.	SH3D19 isoform 6.	0.815
COX17	PUM1	ENSPPYP00000015109	ENSPPYP00000001871	Cytochrome c oxidase copper chaperone COX17.	Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...]	0.748
COX17	PUM2	ENSPPYP00000015109	ENSPPYP00000014090	Cytochrome c oxidase copper chaperone COX17.	Pumilio RNA binding family member 2.	0.748
FUBP3	CLINT1	ENSPPYP00000022072	ENSPPYP00000017899	Far upstream element binding protein 3.	CLINT1 isoform 1.	0.450
FUBP3	PUM1	ENSPPYP00000022072	ENSPPYP00000001871	Far upstream element binding protein 3.	Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...]	0.814
FUBP3	PUM2	ENSPPYP00000022072	ENSPPYP00000014090	Far upstream element binding protein 3.	Pumilio RNA binding family member 2.	0.505
MRPL19	PUM1	ENSPPYP00000013666	ENSPPYP00000001871	39S ribosomal protein L19, mitochondrial; Belongs to the bacterial ribosomal protein bL19 family.	Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...]	0.710
MRPL19	PUM2	ENSPPYP00000013666	ENSPPYP00000014090	39S ribosomal protein L19, mitochondrial; Belongs to the bacterial ribosomal protein bL19 family.	Pumilio RNA binding family member 2.	0.646
PUM1	ATXN1	ENSPPYP00000001871	ENSPPYP00000018177	Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...]	ATXN1 isoform 1.	0.912
PUM1	ATXN1L	ENSPPYP00000001871	ENSPPYP00000024016	Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...]	ATXN1L isoform 2.	0.901
PUM1	CLINT1	ENSPPYP00000001871	ENSPPYP00000017899	Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...]	CLINT1 isoform 1.	0.861

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