STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PUM1Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...] (1212 aa)    
Predicted Functional Partners:
CLINT1
CLINT1 isoform 1.
   
 
 0.921
SH3D19
SH3D19 isoform 6.
     
 0.888
GAK
GAK isoform 7.
   
 0.884
NANOS3
NANOS3 isoform 4; Belongs to the nanos family.
   
 
 0.667
NANOS2
Nanos C2HC-type zinc finger 2; Belongs to the nanos family.
   
 
 0.667
CNOT7
CCR4-NOT transcription complex subunit 7.
    
 
 0.629
COX17
Cytochrome c oxidase copper chaperone COX17.
    
 
 0.621
MRPL19
39S ribosomal protein L19, mitochondrial; Belongs to the bacterial ribosomal protein bL19 family.
    
 
 0.604
RBFOX2
RNA binding fox-1 homolog 2.
   
 
 0.597
DAZL
DAZ1 isoform 1.
    
 
 0.585
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.