OPRD1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNAI2	GNAI3	ENSPPYP00000015499	ENSPPYP00000001241	GNAI2 isoform 1.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.997
GNAI2	OGFRL1	ENSPPYP00000015499	ENSPPYP00000018760	GNAI2 isoform 1.	OGFRL1 isoform 1.	0.650
GNAI2	OPRD1	ENSPPYP00000015499	ENSPPYP00000001886	GNAI2 isoform 1.	Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family.	0.954
GNAI2	OPRK1	ENSPPYP00000015499	ENSPPYP00000020843	GNAI2 isoform 1.	Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family.	0.850
GNAI2	OPRM1	ENSPPYP00000015499	ENSPPYP00000024191	GNAI2 isoform 1.	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family.	0.955
GNAI2	POMC	ENSPPYP00000015499	ENSPPYP00000014061	GNAI2 isoform 1.	POMC isoform 1.	0.415
GNAI3	GNAI2	ENSPPYP00000001241	ENSPPYP00000015499	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	GNAI2 isoform 1.	0.997
GNAI3	OGFRL1	ENSPPYP00000001241	ENSPPYP00000018760	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	OGFRL1 isoform 1.	0.650
GNAI3	OPRD1	ENSPPYP00000001241	ENSPPYP00000001886	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family.	0.958
GNAI3	OPRK1	ENSPPYP00000001241	ENSPPYP00000020843	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family.	0.892
GNAI3	OPRM1	ENSPPYP00000001241	ENSPPYP00000024191	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family.	0.967
GNAI3	PNOC	ENSPPYP00000001241	ENSPPYP00000020706	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Prepronociceptin.	0.402
GNAI3	POMC	ENSPPYP00000001241	ENSPPYP00000014061	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	POMC isoform 1.	0.481
KNG1	OPRD1	ENSPPYP00000016088	ENSPPYP00000001886	KNG1 isoform 1.	Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family.	0.933
KNG1	OPRM1	ENSPPYP00000016088	ENSPPYP00000024191	KNG1 isoform 1.	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family.	0.427
KNG1	PDYN	ENSPPYP00000016088	ENSPPYP00000012111	KNG1 isoform 1.	PDYN isoform 1.	0.562
KNG1	POMC	ENSPPYP00000016088	ENSPPYP00000014061	KNG1 isoform 1.	POMC isoform 1.	0.544
OGFRL1	GNAI2	ENSPPYP00000018760	ENSPPYP00000015499	OGFRL1 isoform 1.	GNAI2 isoform 1.	0.650
OGFRL1	GNAI3	ENSPPYP00000018760	ENSPPYP00000001241	OGFRL1 isoform 1.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.650
OGFRL1	OPRD1	ENSPPYP00000018760	ENSPPYP00000001886	OGFRL1 isoform 1.	Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family.	0.936