| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CNOT7 | YTHDF1 | ENSPPYP00000020597 | ENSPPYP00000012542 | CCR4-NOT transcription complex subunit 7. | YTHDF1 isoform 1. | 0.533 |
| CNOT7 | YTHDF2 | ENSPPYP00000020597 | ENSPPYP00000001887 | CCR4-NOT transcription complex subunit 7. | YTHDF2 isoform 2. | 0.670 |
| CNOT7 | YTHDF3 | ENSPPYP00000020597 | ENSPPYP00000020890 | CCR4-NOT transcription complex subunit 7. | YTH domain-containing family protein 3; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs and promotes RNA translation efficiency (By similarity). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (By similarity). Shares m6A- containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context (By similarity). Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRN [...] | 0.670 |
| EIF4G2 | G3BP1 | ENSPPYP00000004000 | ENSPPYP00000017869 | Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity); Belongs to the eukaryotic initiation factor 4G family. | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | 0.424 |
| EIF4G2 | HNRNPU | ENSPPYP00000004000 | ENSPPYP00000000049 | Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity); Belongs to the eukaryotic initiation factor 4G family. | HNRNPU isoform 9. | 0.587 |
| EIF4G2 | YTHDF1 | ENSPPYP00000004000 | ENSPPYP00000012542 | Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity); Belongs to the eukaryotic initiation factor 4G family. | YTHDF1 isoform 1. | 0.479 |
| EIF4G2 | YTHDF2 | ENSPPYP00000004000 | ENSPPYP00000001887 | Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity); Belongs to the eukaryotic initiation factor 4G family. | YTHDF2 isoform 2. | 0.736 |
| EIF4G2 | YTHDF3 | ENSPPYP00000004000 | ENSPPYP00000020890 | Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity); Belongs to the eukaryotic initiation factor 4G family. | YTH domain-containing family protein 3; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs and promotes RNA translation efficiency (By similarity). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (By similarity). Shares m6A- containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context (By similarity). Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRN [...] | 0.752 |
| G3BP1 | EIF4G2 | ENSPPYP00000017869 | ENSPPYP00000004000 | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity); Belongs to the eukaryotic initiation factor 4G family. | 0.424 |
| G3BP1 | IGF2BP1 | ENSPPYP00000017869 | ENSPPYP00000010002 | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | Insulin like growth factor 2 mRNA binding protein 1. | 0.718 |
| G3BP1 | PRRC2C | ENSPPYP00000017869 | ENSPPYP00000000594 | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | PRRC2C isoform 4. | 0.635 |
| G3BP1 | YTHDF1 | ENSPPYP00000017869 | ENSPPYP00000012542 | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | YTHDF1 isoform 1. | 0.826 |
| G3BP1 | YTHDF2 | ENSPPYP00000017869 | ENSPPYP00000001887 | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | YTHDF2 isoform 2. | 0.828 |
| G3BP1 | YTHDF3 | ENSPPYP00000017869 | ENSPPYP00000020890 | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | YTH domain-containing family protein 3; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs and promotes RNA translation efficiency (By similarity). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (By similarity). Shares m6A- containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context (By similarity). Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRN [...] | 0.638 |
| HNRNPU | EIF4G2 | ENSPPYP00000000049 | ENSPPYP00000004000 | HNRNPU isoform 9. | Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity); Belongs to the eukaryotic initiation factor 4G family. | 0.587 |
| HNRNPU | IGF2BP1 | ENSPPYP00000000049 | ENSPPYP00000010002 | HNRNPU isoform 9. | Insulin like growth factor 2 mRNA binding protein 1. | 0.868 |
| HNRNPU | PRRC2C | ENSPPYP00000000049 | ENSPPYP00000000594 | HNRNPU isoform 9. | PRRC2C isoform 4. | 0.531 |
| HNRNPU | YTHDF2 | ENSPPYP00000000049 | ENSPPYP00000001887 | HNRNPU isoform 9. | YTHDF2 isoform 2. | 0.664 |
| HNRNPU | YTHDF3 | ENSPPYP00000000049 | ENSPPYP00000020890 | HNRNPU isoform 9. | YTH domain-containing family protein 3; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs and promotes RNA translation efficiency (By similarity). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (By similarity). Shares m6A- containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context (By similarity). Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRN [...] | 0.440 |
| IGF2BP1 | G3BP1 | ENSPPYP00000010002 | ENSPPYP00000017869 | Insulin like growth factor 2 mRNA binding protein 1. | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | 0.718 |
