RPA2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RPA2

Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRI [...] (343 aa)

Predicted Functional Partners:

RPA3

0.998

RMI1

0.995

BLM

0.994

FANCM

0.989

WRN

0.987

XPA

0.980

SMARCAL1

0.972

RAD52

0.971

TOP3B

0.950

CLSPN

0.943

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	CLSPN	ENSPPYP00000007694	ENSPPYP00000001791	BLM isoform 1.	CLSPN isoform 4.	0.563
BLM	FANCM	ENSPPYP00000007694	ENSPPYP00000006571	BLM isoform 1.	FANCM isoform 2.	0.995
BLM	RAD52	ENSPPYP00000007694	ENSPPYP00000004716	BLM isoform 1.	RAD52 homolog, DNA repair protein.	0.812
BLM	RMI1	ENSPPYP00000007694	ENSPPYP00000021659	BLM isoform 1.	RMI1 isoform 1.	0.999
BLM	RPA2	ENSPPYP00000007694	ENSPPYP00000001907	BLM isoform 1.	Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRI [...]	0.994
BLM	RPA3	ENSPPYP00000007694	ENSPPYP00000019939	BLM isoform 1.	Replication protein A3.	0.999
BLM	SMARCAL1	ENSPPYP00000007694	ENSPPYP00000014699	BLM isoform 1.	SMARCAL1 isoform 2; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.432
BLM	TOP3B	ENSPPYP00000007694	ENSPPYP00000013399	BLM isoform 1.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.951
BLM	WRN	ENSPPYP00000007694	ENSPPYP00000020730	BLM isoform 1.	WRN isoform 1.	0.659
CLSPN	BLM	ENSPPYP00000001791	ENSPPYP00000007694	CLSPN isoform 4.	BLM isoform 1.	0.563
CLSPN	RPA2	ENSPPYP00000001791	ENSPPYP00000001907	CLSPN isoform 4.	Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRI [...]	0.943
CLSPN	RPA3	ENSPPYP00000001791	ENSPPYP00000019939	CLSPN isoform 4.	Replication protein A3.	0.994
CLSPN	SMARCAL1	ENSPPYP00000001791	ENSPPYP00000014699	CLSPN isoform 4.	SMARCAL1 isoform 2; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.431
CLSPN	WRN	ENSPPYP00000001791	ENSPPYP00000020730	CLSPN isoform 4.	WRN isoform 1.	0.779
FANCM	BLM	ENSPPYP00000006571	ENSPPYP00000007694	FANCM isoform 2.	BLM isoform 1.	0.995
FANCM	RAD52	ENSPPYP00000006571	ENSPPYP00000004716	FANCM isoform 2.	RAD52 homolog, DNA repair protein.	0.876
FANCM	RMI1	ENSPPYP00000006571	ENSPPYP00000021659	FANCM isoform 2.	RMI1 isoform 1.	0.999
FANCM	RPA2	ENSPPYP00000006571	ENSPPYP00000001907	FANCM isoform 2.	Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRI [...]	0.989
FANCM	RPA3	ENSPPYP00000006571	ENSPPYP00000019939	FANCM isoform 2.	Replication protein A3.	0.919
FANCM	SMARCAL1	ENSPPYP00000006571	ENSPPYP00000014699	FANCM isoform 2.	SMARCAL1 isoform 2; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.722

page 1 of 5

Server load: low (30%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About