Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
THEMIS2Thymocyte selection associated family member 2. (642 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family.
   
 
 0.794
LAT
LAT isoform 2.
   
 
 0.727
EIF4E3
EIF4E3 isoform 1; Belongs to the eukaryotic initiation factor 4E family.
    
   0.710
SMPDL3B
Acid sphingomyelinase-like phosphodiesterase.
      
 0.626
XKR8
XK-related protein.
      
 0.618
PTPN6
Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.
   
 
 0.586
PIK3AP1
PIK3AP1 isoform 1.
   
  
 0.580
FGL2
FGL2 isoform 1.
   
  
 0.557
BAHD1
Bromo adjacent homology domain containing 1.
      
 0.551
PTPN11
Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.
   
 
 0.543
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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