Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MAP3K6MAP3K6 isoform 1. (1288 aa)    
Predicted Functional Partners:
MAP2K3
Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.
    
0.974
MAP2K6
Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
    
0.974
MAP2K4
Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.
    
 0.815
DAXX
Death domain associated protein.
    
 
 0.782
MAP3K5
MAP3K5 isoform 1.
    
   0.766
CR201_G0002531
TXNDC2 isoform 4.
    
 0.759
ENSPPYP00000016598
annotation not available
    
 0.759
TXN
Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]
    
 0.759
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 
 0.736
TXNDC8
TXNDC8 isoform 3.
    
 0.648
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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