node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDX42 | GPN2 | ENSPPYP00000009583 | ENSPPYP00000001936 | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby c [...] | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | 0.698 |
DDX42 | TMEM35B | ENSPPYP00000009583 | ENSPPYP00000023715 | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby c [...] | Transmembrane protein 35B. | 0.679 |
DDX42 | UROS | ENSPPYP00000009583 | ENSPPYP00000003214 | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby c [...] | Uroporphyrinogen III synthase. | 0.694 |
GPN1 | GPN2 | ENSPPYP00000014003 | ENSPPYP00000001936 | GPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | 0.915 |
GPN1 | POLR2B | ENSPPYP00000014003 | ENSPPYP00000016468 | GPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.863 |
GPN1 | POLR2C | ENSPPYP00000014003 | ENSPPYP00000008349 | GPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. | RNA polymerase II subunit C. | 0.828 |
GPN1 | RPAP1 | ENSPPYP00000014003 | ENSPPYP00000007224 | GPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. | RPAP1 isoform 3. | 0.857 |
GPN2 | DDX42 | ENSPPYP00000001936 | ENSPPYP00000009583 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby c [...] | 0.698 |
GPN2 | GPN1 | ENSPPYP00000001936 | ENSPPYP00000014003 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | GPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. | 0.915 |
GPN2 | ITSN1 | ENSPPYP00000001936 | ENSPPYP00000012707 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | ITSN1 isoform 4. | 0.689 |
GPN2 | ITSN2 | ENSPPYP00000001936 | ENSPPYP00000014069 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | ITSN2 isoform 3. | 0.813 |
GPN2 | POLR2B | ENSPPYP00000001936 | ENSPPYP00000016468 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.911 |
GPN2 | POLR2C | ENSPPYP00000001936 | ENSPPYP00000008349 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | RNA polymerase II subunit C. | 0.758 |
GPN2 | POLR2L | ENSPPYP00000001936 | ENSPPYP00000024243 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | POLR2L isoform 1. | 0.837 |
GPN2 | RPAP1 | ENSPPYP00000001936 | ENSPPYP00000007224 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | RPAP1 isoform 3. | 0.920 |
GPN2 | TMEM35B | ENSPPYP00000001936 | ENSPPYP00000023715 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | Transmembrane protein 35B. | 0.694 |
GPN2 | UROS | ENSPPYP00000001936 | ENSPPYP00000003214 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | Uroporphyrinogen III synthase. | 0.681 |
ITSN1 | GPN2 | ENSPPYP00000012707 | ENSPPYP00000001936 | ITSN1 isoform 4. | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | 0.689 |
ITSN1 | ITSN2 | ENSPPYP00000012707 | ENSPPYP00000014069 | ITSN1 isoform 4. | ITSN2 isoform 3. | 0.918 |
ITSN2 | GPN2 | ENSPPYP00000014069 | ENSPPYP00000001936 | ITSN2 isoform 3. | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | 0.813 |