Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RPS6KA1Ribosomal protein S6 kinase. (735 aa)    
Predicted Functional Partners:
RPS6KA2
Ribosomal protein S6 kinase.
   
  0.996
RPS6KA3
Ribosomal protein S6 kinase.
   
  0.995
MAPK3
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
0.991
TSC2
TSC2 isoform 1.
   
 0.974
TSC1
TSC1 isoform 8.
    
 0.952
CREB1
CREB1 isoform 1.
   
 0.945
RPS6KA6
Ribosomal protein S6 kinase.
   
 
  0.940
ATF4
ATF4 isoform 1.
    
 0.930
ESR1
Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
   
 0.924
KRAS
KRAS proto-oncogene, GTPase.
   
 0.921
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (14%) [HD]