Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CEP85CEP85 isoform 5. (825 aa)    
Predicted Functional Partners:
SOX13
SRY-box transcription factor 13.
    
   0.833
CEP192
CEP192 isoform 7.
    
 
 0.832
SOX5
SOX5 isoform 3.
    
   0.826
RTTN
RTTN isoform 2.
      
 0.724
CCDC150
CCDC150 isoform 5.
      
 0.656
NEMP1
Nuclear envelope integral membrane protein 1; Belongs to the NEMP family.
      
 0.654
CCDC77
CCDC77 isoform 1.
   
  
 0.642
RIBC2
RIBC2 isoform 1.
      
 0.633
PLK4
Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...]
    
 
 0.593
ZNF367
Zinc finger protein 367.
      
 0.591
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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