PDIK1L protein (Pongo abelii) - STRING interaction network

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PDIK1L

Serine/threonine-protein kinase PDIK1L. (343 aa)

Predicted Functional Partners:

C1H1orf174

0.795

CTDSPL2

0.782

ENSPPYP00000022989

0.782

ENSPPYP00000023820

0.740

FKBP5

0.736

PIK3C3

0.733

PIK3R4

0.732

ATG13

0.729

RB1CC1

0.728

ATG101

0.705

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG101	ATG13	ENSPPYP00000005179	ENSPPYP00000003811	ATG101 isoform 1.	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	0.999
ATG101	PDIK1L	ENSPPYP00000005179	ENSPPYP00000001958	ATG101 isoform 1.	Serine/threonine-protein kinase PDIK1L.	0.705
ATG101	PIK3C3	ENSPPYP00000005179	ENSPPYP00000010247	ATG101 isoform 1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.944
ATG101	PIK3R4	ENSPPYP00000005179	ENSPPYP00000015770	ATG101 isoform 1.	Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).	0.985
ATG101	RB1CC1	ENSPPYP00000005179	ENSPPYP00000020840	ATG101 isoform 1.	RB1CC1 isoform 1.	0.999
ATG13	ATG101	ENSPPYP00000003811	ENSPPYP00000005179	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	ATG101 isoform 1.	0.999
ATG13	PDIK1L	ENSPPYP00000003811	ENSPPYP00000001958	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Serine/threonine-protein kinase PDIK1L.	0.729
ATG13	PIK3C3	ENSPPYP00000003811	ENSPPYP00000010247	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.964
ATG13	PIK3R4	ENSPPYP00000003811	ENSPPYP00000015770	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).	0.985
ATG13	RB1CC1	ENSPPYP00000003811	ENSPPYP00000020840	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	RB1CC1 isoform 1.	0.999
C1H1orf174	PDIK1L	ENSPPYP00000002271	ENSPPYP00000001958	C1orf174 isoform 1.	Serine/threonine-protein kinase PDIK1L.	0.795
CTDSPL2	PDIK1L	ENSPPYP00000007286	ENSPPYP00000001958	CTD small phosphatase like 2.	Serine/threonine-protein kinase PDIK1L.	0.782
ENSPPYP00000022989	PDIK1L	ENSPPYP00000022989	ENSPPYP00000001958	annotation not available	Serine/threonine-protein kinase PDIK1L.	0.782
ENSPPYP00000023820	PDIK1L	ENSPPYP00000023820	ENSPPYP00000001958	annotation not available	Serine/threonine-protein kinase PDIK1L.	0.740
FKBP5	PDIK1L	ENSPPYP00000018489	ENSPPYP00000001958	Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity).	Serine/threonine-protein kinase PDIK1L.	0.736
PDIK1L	ATG101	ENSPPYP00000001958	ENSPPYP00000005179	Serine/threonine-protein kinase PDIK1L.	ATG101 isoform 1.	0.705
PDIK1L	ATG13	ENSPPYP00000001958	ENSPPYP00000003811	Serine/threonine-protein kinase PDIK1L.	Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (By similarity).	0.729
PDIK1L	C1H1orf174	ENSPPYP00000001958	ENSPPYP00000002271	Serine/threonine-protein kinase PDIK1L.	C1orf174 isoform 1.	0.795
PDIK1L	CTDSPL2	ENSPPYP00000001958	ENSPPYP00000007286	Serine/threonine-protein kinase PDIK1L.	CTD small phosphatase like 2.	0.782
PDIK1L	ENSPPYP00000022989	ENSPPYP00000001958	ENSPPYP00000022989	Serine/threonine-protein kinase PDIK1L.	annotation not available	0.782