TRIM63 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Score

TRIM63

TRIM63 isoform 2. (353 aa)

Predicted Functional Partners:

TRIM55

0.968

TRIM54

0.958

TTN

0.896

TCAP

0.853

SQSTM1

0.852

MYLK

0.781

UBE2D1

0.763

FBXO32

0.729

FOXO1

0.720

PKM

0.711

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FBXO32	FOXO1	ENSPPYP00000021159	ENSPPYP00000006042	FBXO32 isoform 2.	FOXO1 isoform 1.	0.674
FBXO32	TRIM54	ENSPPYP00000021159	ENSPPYP00000014021	FBXO32 isoform 2.	Tripartite motif-containing protein 54; May bind and stabilize microtubules during myotubes formation.	0.522
FBXO32	TRIM63	ENSPPYP00000021159	ENSPPYP00000001960	FBXO32 isoform 2.	TRIM63 isoform 2.	0.729
FOXO1	FBXO32	ENSPPYP00000006042	ENSPPYP00000021159	FOXO1 isoform 1.	FBXO32 isoform 2.	0.674
FOXO1	TRIM63	ENSPPYP00000006042	ENSPPYP00000001960	FOXO1 isoform 1.	TRIM63 isoform 2.	0.720
MYLK	SQSTM1	ENSPPYP00000015066	ENSPPYP00000018045	MYLK isoform 5.	Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...]	0.420
MYLK	TCAP	ENSPPYP00000015066	ENSPPYP00000009530	MYLK isoform 5.	TCAP isoform 1.	0.878
MYLK	TRIM55	ENSPPYP00000015066	ENSPPYP00000020901	MYLK isoform 5.	TRIM55 isoform 1.	0.611
MYLK	TRIM63	ENSPPYP00000015066	ENSPPYP00000001960	MYLK isoform 5.	TRIM63 isoform 2.	0.781
PKM	TRIM55	ENSPPYP00000007498	ENSPPYP00000020901	Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity).	TRIM55 isoform 1.	0.495
PKM	TRIM63	ENSPPYP00000007498	ENSPPYP00000001960	Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity).	TRIM63 isoform 2.	0.711
SQSTM1	MYLK	ENSPPYP00000018045	ENSPPYP00000015066	Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...]	MYLK isoform 5.	0.420
SQSTM1	TRIM54	ENSPPYP00000018045	ENSPPYP00000014021	Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...]	Tripartite motif-containing protein 54; May bind and stabilize microtubules during myotubes formation.	0.674
SQSTM1	TRIM55	ENSPPYP00000018045	ENSPPYP00000020901	Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...]	TRIM55 isoform 1.	0.734
SQSTM1	TRIM63	ENSPPYP00000018045	ENSPPYP00000001960	Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...]	TRIM63 isoform 2.	0.852
SQSTM1	TTN	ENSPPYP00000018045	ENSPPYP00000014501	Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...]	TTN isoform 4.	0.605
SQSTM1	UBE2D1	ENSPPYP00000018045	ENSPPYP00000002821	Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...]	Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family.	0.517
TCAP	MYLK	ENSPPYP00000009530	ENSPPYP00000015066	TCAP isoform 1.	MYLK isoform 5.	0.878
TCAP	TRIM54	ENSPPYP00000009530	ENSPPYP00000014021	TCAP isoform 1.	Tripartite motif-containing protein 54; May bind and stabilize microtubules during myotubes formation.	0.628
TCAP	TRIM55	ENSPPYP00000009530	ENSPPYP00000020901	TCAP isoform 1.	TRIM55 isoform 1.	0.579