Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MACO1TMEM57 isoform 1. (664 aa)    
Predicted Functional Partners:
SYF2
SYF2 pre-mRNA splicing factor.
   
  
 0.765
SUGT1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.
      
 0.729
DEDD2
Death effector domain containing 2.
      
 0.725
STXBP1
Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity).
      
 0.687
RHCE
RHD isoform 1; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
      
 0.669
TMEM50A
TMEM50A isoform 1.
      
 0.657
C2CD2L
C2CD2L isoform 1.
      
 0.637
YPEL4
Protein yippee-like; Belongs to the yippee family.
      
 0.584
ILKAP
ILK associated serine/threonine phosphatase.
      
 0.569
RANBP10
RAN binding protein 10.
      
 0.564
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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