Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TMEM50ATMEM50A isoform 1. (157 aa)    
Predicted Functional Partners:
SYF2
SYF2 pre-mRNA splicing factor.
      
 0.888
LEPROTL1
Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). Belongs to the OB-RGRP/VPS55 family.
   
 
 0.861
RHCE
RHD isoform 1; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
      
 0.809
ZNF407
ZNF407 isoform 2.
      
 0.673
MACO1
TMEM57 isoform 1.
      
 0.657
TMEM8B
Transmembrane protein 8B.
      
 0.634
CHMP3
Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...]
    
 
 0.632
SPIDR
SPIDR isoform 1.
      
 0.622
TMEM60
Transmembrane protein 60.
      
 0.593
MYOM3
MYOM3 isoform 1.
      
 0.590
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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