CLIC4 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

CLIC4

Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity). (253 aa)

Predicted Functional Partners:

TPRN

0.950

CLIC5

0.932

CLIC2

0.917

CLIC6

0.851

CSK

0.716

CLIC1

0.584

HIVEP2

0.521

CRKL

0.509

BLMH

0.494

CLNS1A

0.490

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLMH	CLIC4	ENSPPYP00000009142	ENSPPYP00000001982	Bleomycin hydrolase; Belongs to the peptidase C1 family.	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	0.494
CLIC1	CLIC2	ENSPPYP00000018400	ENSPPYP00000023402	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.514
CLIC1	CLIC4	ENSPPYP00000018400	ENSPPYP00000001982	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	0.584
CLIC1	TPRN	ENSPPYP00000018400	ENSPPYP00000022217	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	TPRN isoform 2.	0.734
CLIC2	CLIC1	ENSPPYP00000023402	ENSPPYP00000018400	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.514
CLIC2	CLIC4	ENSPPYP00000023402	ENSPPYP00000001982	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	0.917
CLIC2	CLIC5	ENSPPYP00000023402	ENSPPYP00000018643	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.921
CLIC2	CLIC6	ENSPPYP00000023402	ENSPPYP00000012718	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.713
CLIC2	TPRN	ENSPPYP00000023402	ENSPPYP00000022217	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	TPRN isoform 2.	0.828
CLIC4	BLMH	ENSPPYP00000001982	ENSPPYP00000009142	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	Bleomycin hydrolase; Belongs to the peptidase C1 family.	0.494
CLIC4	CLIC1	ENSPPYP00000001982	ENSPPYP00000018400	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.584
CLIC4	CLIC2	ENSPPYP00000001982	ENSPPYP00000023402	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.917
CLIC4	CLIC5	ENSPPYP00000001982	ENSPPYP00000018643	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.932
CLIC4	CLIC6	ENSPPYP00000001982	ENSPPYP00000012718	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.851
CLIC4	CLNS1A	ENSPPYP00000001982	ENSPPYP00000004240	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	Methylosome subunit pICln; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cyto [...]	0.490
CLIC4	CRKL	ENSPPYP00000001982	ENSPPYP00000024295	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	CRKL isoform 1.	0.509
CLIC4	CSK	ENSPPYP00000001982	ENSPPYP00000007539	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	Tyrosine-protein kinase.	0.716
CLIC4	HIVEP2	ENSPPYP00000001982	ENSPPYP00000019100	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	HIVEP2 isoform 1.	0.521
CLIC4	TPRN	ENSPPYP00000001982	ENSPPYP00000022217	Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity).	TPRN isoform 2.	0.950
CLIC5	CLIC2	ENSPPYP00000018643	ENSPPYP00000023402	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.921

page 1 of 2

Server load: low (28%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About