CNR2 protein (Pongo abelii) - STRING interaction network

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Score

CNR2

Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)

Predicted Functional Partners:

GNAI1

0.874

GNB1

0.784

ENSPPYP00000002678

0.751

GNAI2

0.751

ADORA2A

0.633

GPR18

0.588

FAAH

0.558

MGLL

0.549

DRD2

0.537

ARRB2

0.534

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA2A	ARRB2	ENSPPYP00000012991	ENSPPYP00000008826	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	0.457
ADORA2A	CNR2	ENSPPYP00000012991	ENSPPYP00000002001	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.633
ADORA2A	DRD2	ENSPPYP00000012991	ENSPPYP00000004451	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	0.970
ADORA2A	GNB1	ENSPPYP00000012991	ENSPPYP00000002307	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.909
ARRB2	ADORA2A	ENSPPYP00000008826	ENSPPYP00000012991	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.457
ARRB2	CNR2	ENSPPYP00000008826	ENSPPYP00000002001	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.534
ARRB2	DRD2	ENSPPYP00000008826	ENSPPYP00000004451	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	0.987
ARRB2	MGLL	ENSPPYP00000008826	ENSPPYP00000015033	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	Monoglyceride lipase.	0.517
CNR2	ADORA2A	ENSPPYP00000002001	ENSPPYP00000012991	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.633
CNR2	ARRB2	ENSPPYP00000002001	ENSPPYP00000008826	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	0.534
CNR2	DRD2	ENSPPYP00000002001	ENSPPYP00000004451	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	0.537
CNR2	ENSPPYP00000002678	ENSPPYP00000002001	ENSPPYP00000002678	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	annotation not available	0.751
CNR2	FAAH	ENSPPYP00000002001	ENSPPYP00000001617	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	FAAH isoform 2.	0.558
CNR2	GNAI1	ENSPPYP00000002001	ENSPPYP00000020020	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(i) subunit alpha-1.	0.874
CNR2	GNAI2	ENSPPYP00000002001	ENSPPYP00000015499	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	GNAI2 isoform 1.	0.751
CNR2	GNB1	ENSPPYP00000002001	ENSPPYP00000002307	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.784
CNR2	GPR18	ENSPPYP00000002001	ENSPPYP00000006233	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family.	0.588
CNR2	MGLL	ENSPPYP00000002001	ENSPPYP00000015033	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	Monoglyceride lipase.	0.549
DRD2	ADORA2A	ENSPPYP00000004451	ENSPPYP00000012991	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.970
DRD2	ARRB2	ENSPPYP00000004451	ENSPPYP00000008826	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...]	0.987