ELOA protein (Pongo abelii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ELOA

ELOA isoform 1. (780 aa)

Predicted Functional Partners:

LEO1

0.984

ENSPPYP00000004644

0.960

ELOB

0.960

ELOC

0.953

ENSPPYP00000023677

0.953

CTR9

0.878

CUL5

0.837

WDR61

0.780

POLR2B

0.759

REXO1

0.757

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTR9	ELOA	ENSPPYP00000004001	ENSPPYP00000002009	CTR9 isoform 1.	ELOA isoform 1.	0.878
CTR9	ELOB	ENSPPYP00000004001	ENSPPYP00000007934	CTR9 isoform 1.	ELOB isoform 1.	0.691
CTR9	ELOC	ENSPPYP00000004001	ENSPPYP00000020952	CTR9 isoform 1.	ELOC isoform 10; Belongs to the SKP1 family.	0.546
CTR9	ENSPPYP00000004644	ENSPPYP00000004001	ENSPPYP00000004644	CTR9 isoform 1.	annotation not available	0.691
CTR9	ENSPPYP00000023677	ENSPPYP00000004001	ENSPPYP00000023677	CTR9 isoform 1.	annotation not available	0.546
CTR9	LEO1	ENSPPYP00000004001	ENSPPYP00000007344	CTR9 isoform 1.	RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...]	0.999
CTR9	POLR2B	ENSPPYP00000004001	ENSPPYP00000016468	CTR9 isoform 1.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.929
CTR9	WDR61	ENSPPYP00000004001	ENSPPYP00000007597	CTR9 isoform 1.	WD repeat domain 61.	0.999
CUL5	ELOA	ENSPPYP00000004398	ENSPPYP00000002009	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	ELOA isoform 1.	0.837
CUL5	ELOB	ENSPPYP00000004398	ENSPPYP00000007934	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	ELOB isoform 1.	0.995
CUL5	ELOC	ENSPPYP00000004398	ENSPPYP00000020952	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	ELOC isoform 10; Belongs to the SKP1 family.	0.995
CUL5	ENSPPYP00000004644	ENSPPYP00000004398	ENSPPYP00000004644	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	annotation not available	0.983
CUL5	ENSPPYP00000023677	ENSPPYP00000004398	ENSPPYP00000023677	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	annotation not available	0.983
ELOA	CTR9	ENSPPYP00000002009	ENSPPYP00000004001	ELOA isoform 1.	CTR9 isoform 1.	0.878
ELOA	CUL5	ENSPPYP00000002009	ENSPPYP00000004398	ELOA isoform 1.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.837
ELOA	ELOB	ENSPPYP00000002009	ENSPPYP00000007934	ELOA isoform 1.	ELOB isoform 1.	0.960
ELOA	ELOC	ENSPPYP00000002009	ENSPPYP00000020952	ELOA isoform 1.	ELOC isoform 10; Belongs to the SKP1 family.	0.953
ELOA	ENSPPYP00000004644	ENSPPYP00000002009	ENSPPYP00000004644	ELOA isoform 1.	annotation not available	0.960
ELOA	ENSPPYP00000023677	ENSPPYP00000002009	ENSPPYP00000023677	ELOA isoform 1.	annotation not available	0.953
ELOA	LEO1	ENSPPYP00000002009	ENSPPYP00000007344	ELOA isoform 1.	RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...]	0.984