ELOA protein (Pongo abelii) - STRING interaction network

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[Homology]

Score

ELOA

ELOA isoform 1. (780 aa)

Predicted Functional Partners:

ELOB

0.972

ELOC

0.952

ENSPPYP00000004644

0.940

ENSPPYP00000023677

0.926

LEO1

0.920

CUL5

0.917

CTR9

0.914

POLR2A

0.843

SUPT6H

0.803

REXO1

0.798

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTR9	ELOA	ENSPPYP00000004001	ENSPPYP00000002009	CTR9 isoform 1.	ELOA isoform 1.	0.914
CTR9	ELOB	ENSPPYP00000004001	ENSPPYP00000007934	CTR9 isoform 1.	ELOB isoform 1.	0.601
CTR9	ELOC	ENSPPYP00000004001	ENSPPYP00000020952	CTR9 isoform 1.	ELOC isoform 10; Belongs to the SKP1 family.	0.591
CTR9	ENSPPYP00000004644	ENSPPYP00000004001	ENSPPYP00000004644	CTR9 isoform 1.	annotation not available	0.601
CTR9	ENSPPYP00000023677	ENSPPYP00000004001	ENSPPYP00000023677	CTR9 isoform 1.	annotation not available	0.591
CTR9	LEO1	ENSPPYP00000004001	ENSPPYP00000007344	CTR9 isoform 1.	RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...]	0.999
CTR9	POLR2A	ENSPPYP00000004001	ENSPPYP00000008911	CTR9 isoform 1.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.896
CTR9	SUPT6H	ENSPPYP00000004001	ENSPPYP00000009113	CTR9 isoform 1.	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family.	0.921
CUL5	ELOA	ENSPPYP00000004398	ENSPPYP00000002009	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	ELOA isoform 1.	0.917
CUL5	ELOB	ENSPPYP00000004398	ENSPPYP00000007934	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	ELOB isoform 1.	0.996
CUL5	ELOC	ENSPPYP00000004398	ENSPPYP00000020952	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	ELOC isoform 10; Belongs to the SKP1 family.	0.997
CUL5	ENSPPYP00000004644	ENSPPYP00000004398	ENSPPYP00000004644	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	annotation not available	0.992
CUL5	ENSPPYP00000023677	ENSPPYP00000004398	ENSPPYP00000023677	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	annotation not available	0.973
ELOA	CTR9	ENSPPYP00000002009	ENSPPYP00000004001	ELOA isoform 1.	CTR9 isoform 1.	0.914
ELOA	CUL5	ENSPPYP00000002009	ENSPPYP00000004398	ELOA isoform 1.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.917
ELOA	ELOB	ENSPPYP00000002009	ENSPPYP00000007934	ELOA isoform 1.	ELOB isoform 1.	0.972
ELOA	ELOC	ENSPPYP00000002009	ENSPPYP00000020952	ELOA isoform 1.	ELOC isoform 10; Belongs to the SKP1 family.	0.952
ELOA	ENSPPYP00000004644	ENSPPYP00000002009	ENSPPYP00000004644	ELOA isoform 1.	annotation not available	0.940
ELOA	ENSPPYP00000023677	ENSPPYP00000002009	ENSPPYP00000023677	ELOA isoform 1.	annotation not available	0.926
ELOA	LEO1	ENSPPYP00000002009	ENSPPYP00000007344	ELOA isoform 1.	RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...]	0.920