Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
E2F2E2F2 isoform 1. (437 aa)    
Predicted Functional Partners:
RB1
RB1 isoform 1.
   
 0.998
TFDP1
Transcription factor.
   
 0.991
TFDP2
Transcription factor.
   
 0.988
E2F1
E2F1 isoform 1.
  
 
0.984
LOC100457325
Transcription factor Dp-1.
   
 0.976
RBL1
RBL1 isoform 1.
   
 0.975
RBL2
RBL2 isoform 2.
   
 0.972
CCNA2
CCNA2 isoform 1; Belongs to the cyclin family.
   
 0.972
CCNA1
CCNA1 isoform 3; Belongs to the cyclin family.
   
 0.967
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.960
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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