NECAP2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP1G1	AP2A2	ENSPPYP00000008496	ENSPPYP00000003365	AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).	AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family.	0.647
AP1G1	AP2B1	ENSPPYP00000008496	ENSPPYP00000009206	AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).	AP complex subunit beta.	0.980
AP1G1	AP2M1	ENSPPYP00000008496	ENSPPYP00000016043	AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.934
AP1G1	AP2S1	ENSPPYP00000008496	ENSPPYP00000011367	AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).	AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.753
AP1G1	CR201_G0029663	ENSPPYP00000008496	ENSPPYP00000011487	AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.610
AP1G1	EPS15	ENSPPYP00000008496	ENSPPYP00000001582	AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).	Epidermal growth factor receptor pathway substrate 15.	0.775
AP1G1	ITSN1	ENSPPYP00000008496	ENSPPYP00000012707	AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).	ITSN1 isoform 4.	0.558
AP1G1	ITSN2	ENSPPYP00000008496	ENSPPYP00000014069	AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).	ITSN2 isoform 3.	0.683
AP1G1	NECAP1	ENSPPYP00000008496	ENSPPYP00000004834	AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).	Adaptin ear-binding coat-associated protein 1; Involved in endocytosis; Belongs to the NECAP family.	0.826
AP1G1	NECAP2	ENSPPYP00000008496	ENSPPYP00000002112	AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).	NECAP2 isoform 1.	0.919
AP2A2	AP1G1	ENSPPYP00000003365	ENSPPYP00000008496	AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family.	AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).	0.647
AP2A2	AP2B1	ENSPPYP00000003365	ENSPPYP00000009206	AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family.	AP complex subunit beta.	0.999
AP2A2	AP2M1	ENSPPYP00000003365	ENSPPYP00000016043	AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.999
AP2A2	AP2S1	ENSPPYP00000003365	ENSPPYP00000011367	AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family.	AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.999
AP2A2	CR201_G0029663	ENSPPYP00000003365	ENSPPYP00000011487	AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.997
AP2A2	EPS15	ENSPPYP00000003365	ENSPPYP00000001582	AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family.	Epidermal growth factor receptor pathway substrate 15.	0.972
AP2A2	ITSN1	ENSPPYP00000003365	ENSPPYP00000012707	AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family.	ITSN1 isoform 4.	0.905
AP2A2	ITSN2	ENSPPYP00000003365	ENSPPYP00000014069	AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family.	ITSN2 isoform 3.	0.802
AP2A2	NECAP1	ENSPPYP00000003365	ENSPPYP00000004834	AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family.	Adaptin ear-binding coat-associated protein 1; Involved in endocytosis; Belongs to the NECAP family.	0.898
AP2A2	NECAP2	ENSPPYP00000003365	ENSPPYP00000002112	AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family.	NECAP2 isoform 1.	0.967