Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DNAJC16DnaJ homolog subfamily C member 16. (782 aa)    
Predicted Functional Partners:
C1orf194
Chromosome 1 open reading frame 194.
    
 
 0.682
CREBRF
CREBRF isoform 1.
    
 0.665
HSPA12B
HSPA12B isoform 1.
  
 0.638
OGFOD3
OGFOD3 isoform 4.
    
 
 0.637
TMEM161A
TMEM161A isoform 9.
      
 0.635
RIBC1
RIBC1 isoform 4.
    
 
 0.633
CCDC65
CCDC65 isoform 2.
   
 
 0.629
HSPA4
Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.
  
 0.595
PJA2
E3 ubiquitin-protein ligase Praja-2; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.
   
 
 0.588
DNAJC28
DnaJ heat shock protein family (Hsp40) member C28.
      
 0.578
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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