node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | BIRC2 | ENSPPYP00000005543 | ENSPPYP00000004356 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 2. | 0.790 |
APAF1 | BIRC7 | ENSPPYP00000005543 | ENSPPYP00000012543 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 7. | 0.723 |
APAF1 | CASP3 | ENSPPYP00000005543 | ENSPPYP00000017020 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP3 isoform 1; Belongs to the peptidase C14A family. | 0.995 |
APAF1 | CASP9 | ENSPPYP00000005543 | ENSPPYP00000002138 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP9 isoform 2; Belongs to the peptidase C14A family. | 0.999 |
APAF1 | CYCS | ENSPPYP00000005543 | ENSPPYP00000019862 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.999 |
APAF1 | ENSPPYP00000018466 | ENSPPYP00000005543 | ENSPPYP00000018466 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c-like. | 0.995 |
APAF1 | ENSPPYP00000021735 | ENSPPYP00000005543 | ENSPPYP00000021735 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c-like. | 0.994 |
APAF1 | PARP1 | ENSPPYP00000005543 | ENSPPYP00000000162 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.570 |
APAF1 | XIAP | ENSPPYP00000005543 | ENSPPYP00000023167 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | XIAP isoform 2. | 0.913 |
BIRC2 | APAF1 | ENSPPYP00000004356 | ENSPPYP00000005543 | Baculoviral IAP repeat containing 2. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.790 |
BIRC2 | BIRC7 | ENSPPYP00000004356 | ENSPPYP00000012543 | Baculoviral IAP repeat containing 2. | Baculoviral IAP repeat containing 7. | 0.986 |
BIRC2 | CASP3 | ENSPPYP00000004356 | ENSPPYP00000017020 | Baculoviral IAP repeat containing 2. | CASP3 isoform 1; Belongs to the peptidase C14A family. | 0.995 |
BIRC2 | CASP9 | ENSPPYP00000004356 | ENSPPYP00000002138 | Baculoviral IAP repeat containing 2. | CASP9 isoform 2; Belongs to the peptidase C14A family. | 0.997 |
BIRC2 | CYCS | ENSPPYP00000004356 | ENSPPYP00000019862 | Baculoviral IAP repeat containing 2. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.562 |
BIRC2 | PARP1 | ENSPPYP00000004356 | ENSPPYP00000000162 | Baculoviral IAP repeat containing 2. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.436 |
BIRC2 | XIAP | ENSPPYP00000004356 | ENSPPYP00000023167 | Baculoviral IAP repeat containing 2. | XIAP isoform 2. | 0.997 |
BIRC7 | APAF1 | ENSPPYP00000012543 | ENSPPYP00000005543 | Baculoviral IAP repeat containing 7. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.723 |
BIRC7 | BIRC2 | ENSPPYP00000012543 | ENSPPYP00000004356 | Baculoviral IAP repeat containing 7. | Baculoviral IAP repeat containing 2. | 0.986 |
BIRC7 | CASP3 | ENSPPYP00000012543 | ENSPPYP00000017020 | Baculoviral IAP repeat containing 7. | CASP3 isoform 1; Belongs to the peptidase C14A family. | 0.982 |
BIRC7 | CASP9 | ENSPPYP00000012543 | ENSPPYP00000002138 | Baculoviral IAP repeat containing 7. | CASP9 isoform 2; Belongs to the peptidase C14A family. | 0.996 |