KIAA2013 protein (Pongo abelii) - STRING interaction network

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Score

KIAA2013

KIAA2013 isoform 1. (634 aa)

Predicted Functional Partners:

RCC2

0.847

MYO1D

0.841

ATP6V0D1

0.802

ATP6V0D2

0.802

ATP6AP2

0.800

CCDC115

0.796

ATP6AP1

0.795

PDXDC1

0.792

VMA21

0.779

ATP6V0C

0.778

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6AP1	ATP6AP2	ENSPPYP00000023369	ENSPPYP00000022663	ATPase H+ transporting accessory protein 1.	Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...]	0.998
ATP6AP1	ATP6V0C	ENSPPYP00000023369	ENSPPYP00000007925	ATPase H+ transporting accessory protein 1.	V-type H+-transporting ATPase 16kDa proteolipid subunit.	0.981
ATP6AP1	ATP6V0D1	ENSPPYP00000023369	ENSPPYP00000008426	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the acti [...]	0.992
ATP6AP1	ATP6V0D2	ENSPPYP00000023369	ENSPPYP00000020999	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family.	0.989
ATP6AP1	CCDC115	ENSPPYP00000023369	ENSPPYP00000014964	ATPase H+ transporting accessory protein 1.	CCDC115 isoform 1.	0.837
ATP6AP1	KIAA2013	ENSPPYP00000023369	ENSPPYP00000002170	ATPase H+ transporting accessory protein 1.	KIAA2013 isoform 1.	0.795
ATP6AP1	VMA21	ENSPPYP00000023369	ENSPPYP00000023305	ATPase H+ transporting accessory protein 1.	Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.	0.432
ATP6AP2	ATP6AP1	ENSPPYP00000022663	ENSPPYP00000023369	Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...]	ATPase H+ transporting accessory protein 1.	0.998
ATP6AP2	ATP6V0C	ENSPPYP00000022663	ENSPPYP00000007925	Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...]	V-type H+-transporting ATPase 16kDa proteolipid subunit.	0.981
ATP6AP2	ATP6V0D1	ENSPPYP00000022663	ENSPPYP00000008426	Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...]	V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the acti [...]	0.997
ATP6AP2	ATP6V0D2	ENSPPYP00000022663	ENSPPYP00000020999	Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...]	V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family.	0.980
ATP6AP2	CCDC115	ENSPPYP00000022663	ENSPPYP00000014964	Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...]	CCDC115 isoform 1.	0.920
ATP6AP2	KIAA2013	ENSPPYP00000022663	ENSPPYP00000002170	Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...]	KIAA2013 isoform 1.	0.800
ATP6AP2	VMA21	ENSPPYP00000022663	ENSPPYP00000023305	Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...]	Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.	0.828
ATP6V0C	ATP6AP1	ENSPPYP00000007925	ENSPPYP00000023369	V-type H+-transporting ATPase 16kDa proteolipid subunit.	ATPase H+ transporting accessory protein 1.	0.981
ATP6V0C	ATP6AP2	ENSPPYP00000007925	ENSPPYP00000022663	V-type H+-transporting ATPase 16kDa proteolipid subunit.	Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...]	0.981
ATP6V0C	ATP6V0D1	ENSPPYP00000007925	ENSPPYP00000008426	V-type H+-transporting ATPase 16kDa proteolipid subunit.	V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the acti [...]	0.998
ATP6V0C	ATP6V0D2	ENSPPYP00000007925	ENSPPYP00000020999	V-type H+-transporting ATPase 16kDa proteolipid subunit.	V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family.	0.998
ATP6V0C	CCDC115	ENSPPYP00000007925	ENSPPYP00000014964	V-type H+-transporting ATPase 16kDa proteolipid subunit.	CCDC115 isoform 1.	0.457
ATP6V0C	KIAA2013	ENSPPYP00000007925	ENSPPYP00000002170	V-type H+-transporting ATPase 16kDa proteolipid subunit.	KIAA2013 isoform 1.	0.778