Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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AGTRAPType-1 angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II- stimulated transcriptional activity (By similarity). (159 aa)    
Predicted Functional Partners:
AGTR1
Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.
    
 
 0.786
CR201_G0023978
PITPNC1 isoform 2.
    
 
 0.768
PBX3
PBX3 isoform 3.
    
   0.709
SWT1
SWT1 RNA endoribonuclease homolog.
      
 0.591
CAMLG
Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.
      
 0.578
GDNF
GDNF isoform 6.
    
   0.570
AGT
AGT isoform 1; Belongs to the serpin family.
      
 0.568
GTF2H5
General transcription factor IIH subunit 5.
      
 0.528
CR201_G0025762
Nicotinamide-nucleotide adenylyltransferase.
      
 0.518
ACE2
Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]
    
 
 0.504
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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