SKI protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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[Homology]

Score

SKI

SKI isoform 1. (406 aa)

Predicted Functional Partners:

SMAD4

0.998

SKIL

0.995

NCOR1

0.986

SIN3A

0.980

SMAD3

0.969

SMAD2

0.962

HDAC1

0.925

ENSPPYP00000016868

0.908

SMAD1

0.908

CR201_G0000132

0.896

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0000132	ENSPPYP00000016868	ENSPPYP00000006021	ENSPPYP00000016868	SMAD1 isoform 8.	annotation not available	0.928
CR201_G0000132	SKI	ENSPPYP00000006021	ENSPPYP00000002297	SMAD1 isoform 8.	SKI isoform 1.	0.896
CR201_G0000132	SKIL	ENSPPYP00000006021	ENSPPYP00000015973	SMAD1 isoform 8.	Ski-like protein; May have regulatory role in cell division or differentiation in response to extracellular signals.	0.641
CR201_G0000132	SMAD1	ENSPPYP00000006021	ENSPPYP00000016869	SMAD1 isoform 8.	Mothers against decapentaplegic homolog.	0.928
CR201_G0000132	SMAD2	ENSPPYP00000006021	ENSPPYP00000010275	SMAD1 isoform 8.	Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...]	0.970
CR201_G0000132	SMAD3	ENSPPYP00000006021	ENSPPYP00000007465	SMAD1 isoform 8.	Mothers against decapentaplegic homolog.	0.991
CR201_G0000132	SMAD4	ENSPPYP00000006021	ENSPPYP00000010297	SMAD1 isoform 8.	Mothers against decapentaplegic homolog.	0.999
ENSPPYP00000016868	CR201_G0000132	ENSPPYP00000016868	ENSPPYP00000006021	annotation not available	SMAD1 isoform 8.	0.928
ENSPPYP00000016868	SKI	ENSPPYP00000016868	ENSPPYP00000002297	annotation not available	SKI isoform 1.	0.908
ENSPPYP00000016868	SKIL	ENSPPYP00000016868	ENSPPYP00000015973	annotation not available	Ski-like protein; May have regulatory role in cell division or differentiation in response to extracellular signals.	0.718
ENSPPYP00000016868	SMAD1	ENSPPYP00000016868	ENSPPYP00000016869	annotation not available	Mothers against decapentaplegic homolog.	0.639
ENSPPYP00000016868	SMAD2	ENSPPYP00000016868	ENSPPYP00000010275	annotation not available	Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...]	0.840
ENSPPYP00000016868	SMAD3	ENSPPYP00000016868	ENSPPYP00000007465	annotation not available	Mothers against decapentaplegic homolog.	0.667
ENSPPYP00000016868	SMAD4	ENSPPYP00000016868	ENSPPYP00000010297	annotation not available	Mothers against decapentaplegic homolog.	0.974
HDAC1	NCOR1	ENSPPYP00000001838	ENSPPYP00000009011	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	NCOR1 isoform 1.	0.961
HDAC1	SIN3A	ENSPPYP00000001838	ENSPPYP00000007556	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	SIN3 transcription regulator family member A.	0.998
HDAC1	SKI	ENSPPYP00000001838	ENSPPYP00000002297	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	SKI isoform 1.	0.925
HDAC1	SKIL	ENSPPYP00000001838	ENSPPYP00000015973	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	Ski-like protein; May have regulatory role in cell division or differentiation in response to extracellular signals.	0.907
HDAC1	SMAD2	ENSPPYP00000001838	ENSPPYP00000010275	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...]	0.889
HDAC1	SMAD3	ENSPPYP00000001838	ENSPPYP00000007465	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...]	Mothers against decapentaplegic homolog.	0.787