| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0020693 | UBA1 | ENSPPYP00000024080 | ENSPPYP00000022706 | T0070593 isoform 1. | UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. | 0.913 |
| CR201_G0020693 | UBA3 | ENSPPYP00000024080 | ENSPPYP00000015351 | T0070593 isoform 1. | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity). | 0.774 |
| CR201_G0020693 | UBA5 | ENSPPYP00000024080 | ENSPPYP00000015785 | T0070593 isoform 1. | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2. | 0.722 |
| CR201_G0020693 | UBA6 | ENSPPYP00000024080 | ENSPPYP00000016457 | T0070593 isoform 1. | UBA6 isoform 1. | 0.813 |
| CR201_G0020693 | UBC | ENSPPYP00000024080 | ENSPPYP00000005811 | T0070593 isoform 1. | UBC isoform 2. | 0.776 |
| CR201_G0020693 | UBE2G2 | ENSPPYP00000024080 | ENSPPYP00000012839 | T0070593 isoform 1. | Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). | 0.583 |
| CR201_G0020693 | UBE2H | ENSPPYP00000024080 | ENSPPYP00000020192 | T0070593 isoform 1. | Ubiquitin conjugating enzyme E2 H; Belongs to the ubiquitin-conjugating enzyme family. | 0.777 |
| CR201_G0020693 | UBE2J2 | ENSPPYP00000024080 | ENSPPYP00000002333 | T0070593 isoform 1. | Ubiquitin conjugating enzyme E2 J2. | 0.785 |
| MARCHF6 | UBC | ENSPPYP00000017141 | ENSPPYP00000005811 | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. | UBC isoform 2. | 0.560 |
| MARCHF6 | UBE2G2 | ENSPPYP00000017141 | ENSPPYP00000012839 | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. | Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). | 0.935 |
| MARCHF6 | UBE2J2 | ENSPPYP00000017141 | ENSPPYP00000002333 | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. | Ubiquitin conjugating enzyme E2 J2. | 0.860 |
| TMEM129 | UBE2J2 | ENSPPYP00000016237 | ENSPPYP00000002333 | Transmembrane protein 129. | Ubiquitin conjugating enzyme E2 J2. | 0.844 |
| UBA1 | CR201_G0020693 | ENSPPYP00000022706 | ENSPPYP00000024080 | UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. | T0070593 isoform 1. | 0.913 |
| UBA1 | UBA3 | ENSPPYP00000022706 | ENSPPYP00000015351 | UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity). | 0.635 |
| UBA1 | UBA5 | ENSPPYP00000022706 | ENSPPYP00000015785 | UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2. | 0.626 |
| UBA1 | UBA6 | ENSPPYP00000022706 | ENSPPYP00000016457 | UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. | UBA6 isoform 1. | 0.978 |
| UBA1 | UBC | ENSPPYP00000022706 | ENSPPYP00000005811 | UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. | UBC isoform 2. | 0.996 |
| UBA1 | UBE2G2 | ENSPPYP00000022706 | ENSPPYP00000012839 | UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. | Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). | 0.961 |
| UBA1 | UBE2H | ENSPPYP00000022706 | ENSPPYP00000020192 | UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. | Ubiquitin conjugating enzyme E2 H; Belongs to the ubiquitin-conjugating enzyme family. | 0.958 |
| UBA1 | UBE2J2 | ENSPPYP00000022706 | ENSPPYP00000002333 | UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. | Ubiquitin conjugating enzyme E2 J2. | 0.793 |
