STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISG15ISG15 ubiquitin like modifier. (165 aa)    
Predicted Functional Partners:
UBA7
UBA7 isoform 1; Belongs to the ubiquitin-activating E1 family.
   
 0.997
HERC5
HERC5 isoform 1.
   
 0.995
DDX58
DDX58 isoform 2.
   
 0.995
USP41
Ubl carboxyl-terminal hydrolase 18; Involved in the regulation of inflammatory response to interferon type 1. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.
   
 0.984
UBE2L6
Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.978
IRF3
IRF3 isoform 6.
   
 0.977
IRF9
Interferon regulatory factor 9.
   
 0.970
CR201_G0039615
EIF2AK2 isoform 5.
   
 
 0.968
MX1
Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity.
   
 0.965
IFIT1
Interferon induced protein with tetratricopeptide repeats 1.
   
 0.959
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.