| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0048368 | CYP51A1 | ENSPPYP00000008619 | ENSPPYP00000019976 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.622 |
| CR201_G0048368 | ENSPPYP00000019579 | ENSPPYP00000008619 | ENSPPYP00000019579 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | annotation not available | 0.688 |
| CR201_G0048368 | FDPS | ENSPPYP00000008619 | ENSPPYP00000000868 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | FDPS isoform 12; Belongs to the FPP/GGPP synthase family. | 0.724 |
| CR201_G0048368 | GGPS1 | ENSPPYP00000008619 | ENSPPYP00000000097 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | GGPS1 isoform 1; Belongs to the FPP/GGPP synthase family. | 0.637 |
| CR201_G0048368 | HMGCS1 | ENSPPYP00000008619 | ENSPPYP00000017251 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.758 |
| CR201_G0048368 | IDI1 | ENSPPYP00000008619 | ENSPPYP00000002358 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.950 |
| CR201_G0048368 | LSS | ENSPPYP00000008619 | ENSPPYP00000012870 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. | 0.686 |
| CR201_G0048368 | SQLE | ENSPPYP00000008619 | ENSPPYP00000021174 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | SQLE isoform 1. | 0.688 |
| CYP51A1 | CR201_G0048368 | ENSPPYP00000019976 | ENSPPYP00000008619 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.622 |
| CYP51A1 | ENSPPYP00000019579 | ENSPPYP00000019976 | ENSPPYP00000019579 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | annotation not available | 0.568 |
| CYP51A1 | FDPS | ENSPPYP00000019976 | ENSPPYP00000000868 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | FDPS isoform 12; Belongs to the FPP/GGPP synthase family. | 0.648 |
| CYP51A1 | HMGCS1 | ENSPPYP00000019976 | ENSPPYP00000017251 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.962 |
| CYP51A1 | IDI1 | ENSPPYP00000019976 | ENSPPYP00000002358 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.927 |
| CYP51A1 | LSS | ENSPPYP00000019976 | ENSPPYP00000012870 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. | 0.997 |
| CYP51A1 | MVD | ENSPPYP00000019976 | ENSPPYP00000024028 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | MVD isoform 2. | 0.622 |
| CYP51A1 | SQLE | ENSPPYP00000019976 | ENSPPYP00000021174 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | SQLE isoform 1. | 0.981 |
| ENSPPYP00000019579 | CR201_G0048368 | ENSPPYP00000019579 | ENSPPYP00000008619 | annotation not available | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.688 |
| ENSPPYP00000019579 | CYP51A1 | ENSPPYP00000019579 | ENSPPYP00000019976 | annotation not available | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.568 |
| ENSPPYP00000019579 | FDPS | ENSPPYP00000019579 | ENSPPYP00000000868 | annotation not available | FDPS isoform 12; Belongs to the FPP/GGPP synthase family. | 0.901 |
| ENSPPYP00000019579 | GGPS1 | ENSPPYP00000019579 | ENSPPYP00000000097 | annotation not available | GGPS1 isoform 1; Belongs to the FPP/GGPP synthase family. | 0.978 |
