FBH1 protein (Pongo abelii) - STRING interaction network

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

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Score

FBH1

FBXO18 isoform 2. (1006 aa)

Predicted Functional Partners:

CUL1

0.953

SKP1

0.944

ENSPPYP00000022319

0.944

FANCM

0.929

PCNA

0.860

RAD51

0.854

XRCC3

0.831

RBX1

0.826

RECQL5

0.819

WRN

0.812

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL1	ENSPPYP00000022319	ENSPPYP00000020352	ENSPPYP00000022319	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	annotation not available	0.985
CUL1	FBH1	ENSPPYP00000020352	ENSPPYP00000002388	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	FBXO18 isoform 2.	0.953
CUL1	RBX1	ENSPPYP00000020352	ENSPPYP00000013235	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	RBX1 isoform 1.	0.999
CUL1	SKP1	ENSPPYP00000020352	ENSPPYP00000017649	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...]	0.994
ENSPPYP00000022319	CUL1	ENSPPYP00000022319	ENSPPYP00000020352	annotation not available	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	0.985
ENSPPYP00000022319	FBH1	ENSPPYP00000022319	ENSPPYP00000002388	annotation not available	FBXO18 isoform 2.	0.944
ENSPPYP00000022319	RBX1	ENSPPYP00000022319	ENSPPYP00000013235	annotation not available	RBX1 isoform 1.	0.985
FANCM	FBH1	ENSPPYP00000006571	ENSPPYP00000002388	FANCM isoform 2.	FBXO18 isoform 2.	0.929
FANCM	PCNA	ENSPPYP00000006571	ENSPPYP00000012059	FANCM isoform 2.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.930
FANCM	RAD51	ENSPPYP00000006571	ENSPPYP00000007198	FANCM isoform 2.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.901
FANCM	RBX1	ENSPPYP00000006571	ENSPPYP00000013235	FANCM isoform 2.	RBX1 isoform 1.	0.427
FANCM	RECQL5	ENSPPYP00000006571	ENSPPYP00000009694	FANCM isoform 2.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.942
FANCM	WRN	ENSPPYP00000006571	ENSPPYP00000020730	FANCM isoform 2.	WRN isoform 1.	0.983
FANCM	XRCC3	ENSPPYP00000006571	ENSPPYP00000007020	FANCM isoform 2.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.822
FBH1	CUL1	ENSPPYP00000002388	ENSPPYP00000020352	FBXO18 isoform 2.	Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...]	0.953
FBH1	ENSPPYP00000022319	ENSPPYP00000002388	ENSPPYP00000022319	FBXO18 isoform 2.	annotation not available	0.944
FBH1	FANCM	ENSPPYP00000002388	ENSPPYP00000006571	FBXO18 isoform 2.	FANCM isoform 2.	0.929
FBH1	PCNA	ENSPPYP00000002388	ENSPPYP00000012059	FBXO18 isoform 2.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.860
FBH1	RAD51	ENSPPYP00000002388	ENSPPYP00000007198	FBXO18 isoform 2.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.854
FBH1	RBX1	ENSPPYP00000002388	ENSPPYP00000013235	FBXO18 isoform 2.	RBX1 isoform 1.	0.826