GATA3 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

Experiments

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[Homology]

Score

GATA3

GATA binding protein 3. (444 aa)

Predicted Functional Partners:

TBX21

0.977

FOXA1

0.975

TAL1

0.972

EP300

0.955

NRIP1

0.917

RUNX1

0.903

ESR1

0.896

TLE3

0.890

STAT6

0.878

ETS1

0.810

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EP300	ESR1	ENSPPYP00000013236	ENSPPYP00000019159	EP300 isoform 1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.982
EP300	ETS1	ENSPPYP00000013236	ENSPPYP00000004632	EP300 isoform 1.	ETS proto-oncogene 1, transcription factor.	0.758
EP300	FOXA1	ENSPPYP00000013236	ENSPPYP00000006542	EP300 isoform 1.	FOXA1 isoform 1.	0.941
EP300	GATA3	ENSPPYP00000013236	ENSPPYP00000002408	EP300 isoform 1.	GATA binding protein 3.	0.955
EP300	NRIP1	ENSPPYP00000013236	ENSPPYP00000012611	EP300 isoform 1.	NRIP1 isoform 1.	0.914
EP300	RUNX1	ENSPPYP00000013236	ENSPPYP00000012719	EP300 isoform 1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.896
EP300	STAT6	ENSPPYP00000013236	ENSPPYP00000005333	EP300 isoform 1.	Signal transducer and activator of transcription.	0.920
EP300	TAL1	ENSPPYP00000013236	ENSPPYP00000001602	EP300 isoform 1.	TAL1 isoform 1.	0.741
EP300	TBX21	ENSPPYP00000013236	ENSPPYP00000009957	EP300 isoform 1.	T-box transcription factor 21.	0.447
EP300	TLE3	ENSPPYP00000013236	ENSPPYP00000007485	EP300 isoform 1.	TLE family member 3, transcriptional corepressor.	0.897
ESR1	EP300	ENSPPYP00000019159	ENSPPYP00000013236	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	EP300 isoform 1.	0.982
ESR1	FOXA1	ENSPPYP00000019159	ENSPPYP00000006542	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	FOXA1 isoform 1.	0.931
ESR1	GATA3	ENSPPYP00000019159	ENSPPYP00000002408	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	GATA binding protein 3.	0.896
ESR1	NRIP1	ENSPPYP00000019159	ENSPPYP00000012611	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	NRIP1 isoform 1.	0.986
ESR1	RUNX1	ENSPPYP00000019159	ENSPPYP00000012719	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.691
ESR1	TLE3	ENSPPYP00000019159	ENSPPYP00000007485	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	TLE family member 3, transcriptional corepressor.	0.514
ETS1	EP300	ENSPPYP00000004632	ENSPPYP00000013236	ETS proto-oncogene 1, transcription factor.	EP300 isoform 1.	0.758
ETS1	GATA3	ENSPPYP00000004632	ENSPPYP00000002408	ETS proto-oncogene 1, transcription factor.	GATA binding protein 3.	0.810
ETS1	RUNX1	ENSPPYP00000004632	ENSPPYP00000012719	ETS proto-oncogene 1, transcription factor.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.985
ETS1	STAT6	ENSPPYP00000004632	ENSPPYP00000005333	ETS proto-oncogene 1, transcription factor.	Signal transducer and activator of transcription.	0.403