| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HTT | MAP1LC3B | ENSPPYP00000016260 | ENSPPYP00000008605 | HTT isoform 1. | MAP1LC3B isoform 1. | 0.413 |
| HTT | OPTN | ENSPPYP00000016260 | ENSPPYP00000002431 | HTT isoform 1. | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] | 0.847 |
| IKBKE | MAP1LC3B | ENSPPYP00000000308 | ENSPPYP00000008605 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | MAP1LC3B isoform 1. | 0.546 |
| IKBKE | OPTN | ENSPPYP00000000308 | ENSPPYP00000002431 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] | 0.847 |
| IKBKE | RIPK1 | ENSPPYP00000000308 | ENSPPYP00000018096 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | Receptor interacting serine/threonine kinase 1. | 0.684 |
| IKBKE | TBK1 | ENSPPYP00000000308 | ENSPPYP00000005386 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | TANK binding kinase 1. | 0.999 |
| IKBKE | TNF | ENSPPYP00000000308 | ENSPPYP00000018379 | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. | 0.964 |
| MAP1LC3B | HTT | ENSPPYP00000008605 | ENSPPYP00000016260 | MAP1LC3B isoform 1. | HTT isoform 1. | 0.413 |
| MAP1LC3B | IKBKE | ENSPPYP00000008605 | ENSPPYP00000000308 | MAP1LC3B isoform 1. | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | 0.546 |
| MAP1LC3B | OPTN | ENSPPYP00000008605 | ENSPPYP00000002431 | MAP1LC3B isoform 1. | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] | 0.851 |
| MAP1LC3B | TBC1D17 | ENSPPYP00000008605 | ENSPPYP00000011494 | MAP1LC3B isoform 1. | TBC1 domain family member 17. | 0.464 |
| MAP1LC3B | TBK1 | ENSPPYP00000008605 | ENSPPYP00000005386 | MAP1LC3B isoform 1. | TANK binding kinase 1. | 0.777 |
| MYO6 | OPTN | ENSPPYP00000018788 | ENSPPYP00000002431 | MYO6 isoform 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] | 0.869 |
| OPTN | HTT | ENSPPYP00000002431 | ENSPPYP00000016260 | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] | HTT isoform 1. | 0.847 |
| OPTN | IKBKE | ENSPPYP00000002431 | ENSPPYP00000000308 | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | 0.847 |
| OPTN | MAP1LC3B | ENSPPYP00000002431 | ENSPPYP00000008605 | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] | MAP1LC3B isoform 1. | 0.851 |
| OPTN | MYO6 | ENSPPYP00000002431 | ENSPPYP00000018788 | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] | MYO6 isoform 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.869 |
| OPTN | RAB8A | ENSPPYP00000002431 | ENSPPYP00000010852 | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | 0.920 |
| OPTN | RAB8B | ENSPPYP00000002431 | ENSPPYP00000024284 | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] | Ras-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). | 0.851 |
| OPTN | RIPK1 | ENSPPYP00000002431 | ENSPPYP00000018096 | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] | Receptor interacting serine/threonine kinase 1. | 0.862 |
