STAM protein (Pongo abelii) - STRING interaction network

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Predicted Interactions

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Score

STAM

Signal transducing adaptor molecule. (540 aa)

Predicted Functional Partners:

CR201_G0021153

0.999

STAMBP

0.997

STAM2

0.992

UBC

0.957

JAK2

0.953

TSG101

0.936

USP8

0.926

JAK1

0.925

ITSN2

0.910

ITSN1

0.891

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0021153	ITSN1	ENSPPYP00000009814	ENSPPYP00000012707	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	ITSN1 isoform 4.	0.886
CR201_G0021153	ITSN2	ENSPPYP00000009814	ENSPPYP00000014069	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	ITSN2 isoform 3.	0.913
CR201_G0021153	STAM	ENSPPYP00000009814	ENSPPYP00000002467	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adaptor molecule.	0.999
CR201_G0021153	STAM2	ENSPPYP00000009814	ENSPPYP00000014344	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	STAM2 isoform 1.	0.997
CR201_G0021153	TSG101	ENSPPYP00000009814	ENSPPYP00000003942	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	TSG101 isoform 4.	0.993
CR201_G0021153	UBC	ENSPPYP00000009814	ENSPPYP00000005811	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	UBC isoform 2.	0.947
CR201_G0021153	USP8	ENSPPYP00000009814	ENSPPYP00000007332	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	USP8 isoform 3; Belongs to the peptidase C19 family.	0.929
ITSN1	CR201_G0021153	ENSPPYP00000012707	ENSPPYP00000009814	ITSN1 isoform 4.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.886
ITSN1	ITSN2	ENSPPYP00000012707	ENSPPYP00000014069	ITSN1 isoform 4.	ITSN2 isoform 3.	0.918
ITSN1	STAM	ENSPPYP00000012707	ENSPPYP00000002467	ITSN1 isoform 4.	Signal transducing adaptor molecule.	0.891
ITSN1	STAM2	ENSPPYP00000012707	ENSPPYP00000014344	ITSN1 isoform 4.	STAM2 isoform 1.	0.891
ITSN2	CR201_G0021153	ENSPPYP00000014069	ENSPPYP00000009814	ITSN2 isoform 3.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.913
ITSN2	ITSN1	ENSPPYP00000014069	ENSPPYP00000012707	ITSN2 isoform 3.	ITSN1 isoform 4.	0.918
ITSN2	JAK1	ENSPPYP00000014069	ENSPPYP00000001481	ITSN2 isoform 3.	Tyrosine-protein kinase.	0.447
ITSN2	JAK2	ENSPPYP00000014069	ENSPPYP00000021551	ITSN2 isoform 3.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.447
ITSN2	STAM	ENSPPYP00000014069	ENSPPYP00000002467	ITSN2 isoform 3.	Signal transducing adaptor molecule.	0.910
ITSN2	STAM2	ENSPPYP00000014069	ENSPPYP00000014344	ITSN2 isoform 3.	STAM2 isoform 1.	0.910
ITSN2	UBC	ENSPPYP00000014069	ENSPPYP00000005811	ITSN2 isoform 3.	UBC isoform 2.	0.534
JAK1	ITSN2	ENSPPYP00000001481	ENSPPYP00000014069	Tyrosine-protein kinase.	ITSN2 isoform 3.	0.447
JAK1	JAK2	ENSPPYP00000001481	ENSPPYP00000021551	Tyrosine-protein kinase.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.998